Palnox 0.25 mg/5 ml (IV Injection)
5 ml ampoule: ৳ 100.30 (1 x 3: ৳ 300.90)
Medicine Details
| Category | Details |
|---|---|
| Generic | Palonosetron |
| Company | Drug international ltd |
| Also available as |
Title
- Palnox
Categories
- Medicine
- Pharmaceutical
Description
- Anti-emetic drug
- Used for acute and delayed nausea and vomiting
- Indicated for uncontrolled nausea and vomiting
- Treatment for chemotherapy-induced nausea and vomiting (CINV)
- Effective for radiotherapy-induced nausea and vomiting (RINV)
- Addresses post-operative & post-discharge nausea and vomiting (PONV & PDNV)
- Pregnancy category 'B'
- Usable in special populations like elderly, children, and patients with impaired renal and hepatic function
- No known antidote for overdose
Dimensions
- Tablet dosage: 0.5mg
- IV dosage: 0.075mg or 0.25mg
Color options
Functions
- 5-HT3 receptor antagonist
- Blocks serotonin action
Materials
Technical specifications
- Usual adult tablet dosage: 0.5mg daily
- Maximum child IV dose: 1.5mg
- Multiple metabolic pathways: liver (CYP2D6, CYP3A4, CYP1A2) and kidney
- Long half-life: 40 hours
- Linear dose-proportional pharmacokinetics over the dose range 1-90μg/kg
- Approximately 40% excreted as unchanged drug in urine after 144 hours
- Volume of distribution: approximately 6.9-7.9 L/kg
Design elements
Usability features
- No known clinically significant drug interactions
- No significant pharmacokinetic interactions with metoclopramide
- Contraindicated in patients with hypersensitivity to the drug or its components
- Headache and constipation are common adverse reactions
Interaction
- Safely administered with corticosteroids, analgesics, antiemetics/antinauseants, antispasmodics, and anticholinergic agents
- Did not inhibit the antitumor activity of certain chemotherapeutic agents in murine tumor models
Contraindications
- Hypersensitivity to the drug or any of its components
Side effects
- Headaches
- Constipation
Pregnancy lactation
- Not known whether excreted in breast milk
Special populations
- No dosage adjustment recommended in elderly patients >65 years of age
- Special dosage for children (1 month to 10 years) at 20μg/kg body weight with a maximum dose of 1.5mg
- No dosage adjustment recommended in patients with renal and hepatic dysfunction
Overdose effects
- No known antidote, managed with supportive care
Storage conditions
- Store in a cool & dry place, protected from light