Palon 0.25 mg/5 ml (IV Injection)
5 ml ampoule: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Palonosetron |
| Company | Pharmasia limited |
| Also available as |
Indications
- Acute and delayed nausea and vomiting
- Uncontrolled nausea and vomiting
- Chemotherapy-induced nausea and vomiting (CINV)
- Radiotherapy-induced nausea and vomiting (RINV)
- Post-operative & Post-discharge nausea and vomiting (PONV & PDNV)
Mode of Action
- 5-HT3 receptor antagonist
- Binding affinity for serotonin receptors
- Inhibition of emetic response
- Pharmacokinetics: linear dose-proportional
- Metabolism and excretion details
Dosage & Administration
- Usual adult tablet dosage of 0.5 mg daily
- Usual adult IV dosage of 0.075 mg over 10 seconds
- Specific dosages for chemotherapy and radiotherapy-induced nausea and vomiting
- Children dosage of 20 mcg/kg body weight
- Maximum children dose of 1.5 mg
Interaction
- Safe administration with corticosteroids, analgesics, antiemetics, antispasmodics, and anticholinergic agents
- No inhibition of antitumor activity of specific drugs
- No significant pharmacokinetic interactions with metoclopramide
- In vitro studies on CYP enzymes
Contraindications
- Hypersensitivity to the drug or any of its components
Side Effects
- Most common adverse reactions: headaches and constipation
Pregnancy & Lactation
- Pregnancy category 'B'
- Unknown excretion in breast milk
Use in Special Populations
- No dosage adjustment in elderly patients >65 years of age
- Specific dosage for children (1 month to 10 years)
- No dosage adjustment in patients with renal and hepatic dysfunction
Overdose Effects
- No known antidote
- Management with supportive care
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store in a cool & dry place, protected from light