Paloset 0.5 mg (Tablet)

Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Palonosetron
Company Square pharmaceuticals plc
Also available as
Paloset 0075 mg injection

Indications

  • Acute and delayed nausea and vomiting
  • Uncontrolled nausea and vomiting
  • Chemotherapy-induced nausea and vomiting (CINV)
  • Radiotherapy-induced nausea and vomiting (RINV)
  • Post-operative & Post-discharge nausea and vomiting (PONV & PDNV)

Pharmacology

  • 5-HT3 receptor antagonist
  • Strong binding affinity for 5-HT3 receptor
  • Little or no affinity for other receptors
  • Influence on emetic response
  • Metabolism and excretion details

Dosage & Administration

  • Adult tablet dosage: 0.5 mg daily
  • Adult IV dosage: 0.075 mg over 10 seconds
  • Chemotherapy-induced nausea and vomiting:
    • Tablet dosage: 0.5 mg approximately 1 hour prior to chemotherapy
    • IV dosage: 0.25 mg over 30 seconds approximately 30 minutes before chemotherapy
  • Radiotherapy-induced nausea and vomiting: IV dosage: 0.25 mg over 30 seconds approximately 30 minutes before each week of radiation
  • Post-operative nausea and vomiting: IV dosage: 0.075 mg over 10 seconds immediately before induction of anesthesia
  • Children dosage:
    • 1 month to 17 years: IV dose at 20 mcg/kg body weight, maximum dose: 1.5 mg

Interaction

  • Safe administration with certain medications
  • No significant pharmacokinetic interactions with metoclopramide
  • No inhibition or induction of specific CYP enzymes
  • Low potential for clinically significant drug interactions

Contraindications

Hypersensitivity to the drug or any of its components

Side Effects

  • Headaches
  • Constipation

Pregnancy & Lactation

Pregnancy category 'B'. Excretion in breast milk is not known

Use in Special Populations

  • No dosage adjustment recommended in elderly patients >65 years
  • Specific dosage for children (1 month to 10 years)
  • No dosage adjustment recommended in patients with renal and hepatic dysfunction

Overdose Effects

No known antidote. Manage with supportive care

Therapeutic Class

Anti-emetic drugs

Storage Conditions

Cool & dry place, protected from light

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