Palostat 0.5 mg (Tablet)
Unit Price: ৳ 20.00 (1 x 10: ৳ 200.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Palonosetron |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Title
- Palostat
Categories
- Anti-emetic drugs
Description
- Palostat is indicated for acute and delayed nausea and vomiting, uncontrolled nausea and vomiting, chemotherapy-induced nausea and vomiting, radiotherapy-induced nausea and vomiting, post-operative and post-discharge nausea and vomiting. It works as a 5-HT3 receptor antagonist.
DosageAndAdministration
- Usual dosage: Adult tablet dosage - 0.5 mg daily, Adult IV dosage - 0.075 mg over 10 seconds. Children dosage: A single IV dose at 20 mcg/kg body weight with maximum dose of 1.5 mg.
Pharmacology
- Palonosetron is a 5-HT3 receptor antagonist with a strong binding affinity for this receptor. It binds to the 5-HT3 receptor and blocks the actions of serotonin, associated with nausea and vomiting.
Interaction
- Palostat has been safely administered with corticosteroids, analgesics, antiemetics/antinauseants, antispasmodics, and anticholinergic agents. Concomitant administration of Palostat and metoclopramide has no significant pharmacokinetic interactions.
Contraindications
- Palostat is contraindicated in patients known to have hypersensitivity to the drug or any of its components.
SideEffects
- The most common adverse reactions are headaches and constipation.
PregnancyAndLactation
- Pregnancy category 'B'. It is not known whether Palonosetron is excreted in breast milk.
SpecialPopulations
- No dosage adjustment is recommended in elderly patients over 65 years of age. No dosage adjustment is recommended in patients with renal and hepatic dysfunction.
OverdoseEffects
- There is no known antidote to Palostat. Overdose should be managed with supportive care.
StorageConditions
- Store in a cool and dry place, protected from light.