Palostat 0.5 mg (Tablet)

Unit Price: ৳ 20.00 (1 x 10: ৳ 200.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Palonosetron
Company Ibn sina pharmaceuticals ltd
Also available as
Palostat 0075 mg injection Palostat 025 mg injection

Title

  • Palostat

Categories

  • Anti-emetic drugs

Description

  • Palostat is indicated for acute and delayed nausea and vomiting, uncontrolled nausea and vomiting, chemotherapy-induced nausea and vomiting, radiotherapy-induced nausea and vomiting, post-operative and post-discharge nausea and vomiting. It works as a 5-HT3 receptor antagonist.

DosageAndAdministration

  • Usual dosage: Adult tablet dosage - 0.5 mg daily, Adult IV dosage - 0.075 mg over 10 seconds. Children dosage: A single IV dose at 20 mcg/kg body weight with maximum dose of 1.5 mg.

Pharmacology

  • Palonosetron is a 5-HT3 receptor antagonist with a strong binding affinity for this receptor. It binds to the 5-HT3 receptor and blocks the actions of serotonin, associated with nausea and vomiting.

Interaction

  • Palostat has been safely administered with corticosteroids, analgesics, antiemetics/antinauseants, antispasmodics, and anticholinergic agents. Concomitant administration of Palostat and metoclopramide has no significant pharmacokinetic interactions.

Contraindications

  • Palostat is contraindicated in patients known to have hypersensitivity to the drug or any of its components.

SideEffects

  • The most common adverse reactions are headaches and constipation.

PregnancyAndLactation

  • Pregnancy category 'B'. It is not known whether Palonosetron is excreted in breast milk.

SpecialPopulations

  • No dosage adjustment is recommended in elderly patients over 65 years of age. No dosage adjustment is recommended in patients with renal and hepatic dysfunction.

OverdoseEffects

  • There is no known antidote to Palostat. Overdose should be managed with supportive care.

StorageConditions

  • Store in a cool and dry place, protected from light.

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