Paloxiron 0.25 mg/5 ml (IV Injection)

5 ml ampoule: ৳ 100.00 (1 x 5: ৳ 500.00)

Medicine Details

Category	Details
Generic	Palonosetron
Company	Incepta pharmaceuticals ltd
Also available as	Paloxiron 0075 mg injection Paloxiron 05 mg tablet

Indications

Acute and delayed nausea and vomiting
Uncontrolled nausea and vomiting
Chemotherapy-induced nausea and vomiting (CINV)
Radiotherapy-induced nausea and vomiting (RINV)
Post-operative & Post-discharge nausea and vomiting (PONV & PDNV)

Pharmacology

5-HT3 receptor antagonist
Binding affinity for serotonin receptor
Pharmacokinetics
Metabolism
Plasma protein binding
Drug clearance
Half-life
Receptor binding affinity

Dosage & Administration

Usual Adult dosage
Chemotherapy-induced nausea and vomiting dosage
Radiotherapy-induced nausea and vomiting dosage
Post-operative nausea and vomiting dosage
Children dosage

Interaction

Safe administration with corticosteroids, analgesics, antiemetics/antinauseants, antispasmodics, anticholinergic agents
No inhibition of antitumor activity
No significant pharmacokinetic interactions
Not inhibitor of CYP enzymes
Low potential for drug interactions

Contraindications

Hypersensitivity to the drug or its components

Side Effects

Headaches
Constipation

Pregnancy & Lactation

Pregnancy category 'B'
Excretion in breast milk unknown

Use in Special Populations

Elderly patients dosage
Children dosage
Use in patients with impaired renal and hepatic function

Overdose Effects

No known antidote
Manage with supportive care

Therapeutic Class

Anti-emetic drugs

Storage Conditions

Store in a cool & dry place
Protected from light

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