Paloxiron 0.5 mg (Tablet)

Unit Price: ৳ 20.00 (1 x 10: ৳ 200.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Palonosetron
Company Incepta pharmaceuticals ltd
Also available as
Paloxiron 0075 mg injection Paloxiron 025 mg injection

Title

Paloxiron

Categories

  • Medicine
  • Anti-emetic drugs

Description

Paloxiron is indicated in the treatment and prevention of acute and delayed nausea and vomiting caused by chemotherapy, radiotherapy, post-operative and post-discharge conditions.

Attributes

  • Indications:
    • Acute and delayed nausea and vomiting
    • Uncontrolled nausea and vomiting
    • Chemotherapy-induced nausea and vomiting
    • Radiotherapy-induced nausea and vomiting
    • Post-operative & Post-discharge nausea and vomiting
  • Mode of Action: Acts as a 5-HT3 receptor antagonist by blocking the actions of Serotonin associated with nausea and vomiting.
  • Pharmacology:
    • Exhibits linear dose-proportional pharmacokinetics
    • Has a longer half-life (40 hours)
    • Metabolized via kidney and liver CYP2D6, CYP3A4, and CYP1A2 isoenzymes
  • Dosage & Administration:
    • Usual adult tablet dosage: 0.5 mg daily
    • Usual adult IV dosage: A single IV dose of 0.075 mg administered over 10 seconds
    • Variations in dosage for different conditions and age groups
  • Interaction: Safely administered with corticosteroids, analgesics, antiemetics, and other medications based on clinical trials. Low potential for clinically significant drug interactions.
  • Contraindications: Contraindicated in patients known to have hypersensitivity to the drug or any of its components.
  • Side Effects:
    • Common adverse reactions include headaches and constipation
  • Pregnancy & Lactation: Pregnancy category 'B'. Excretion in breast milk is not known.
  • Use in Special Populations:
    • No dosage adjustment recommended in elderly patients >65 years of age
    • Specific dosage instructions for children
    • No dosage adjustment recommended in patients with renal and hepatic dysfunction
  • Overdose Effects: No known antidote to Paloxiron. Overdose should be managed with supportive care.
  • Therapeutic Class: Anti-emetic drugs
  • Storage Conditions: Store in a cool & dry place, protected from light

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