Palzen 0.075 mg/1.5 ml (IV Injection)

1.5 ml ampoule: ৳ 90.00 (1 x 5: ৳ 450.00)

Medicine Details

Category	Details
Generic	Palonosetron
Company	Healthcare pharmaceuticals ltd
Also available as	Palzen 025 mg injection Palzen 05 mg tablet

Indications

Acute and delayed nausea and vomiting
Uncontrolled nausea and vomiting
Chemotherapy-induced nausea and vomiting (CINV)
Delayed CINV
Radiotherapy-induced nausea and vomiting (RINV)
Post-operative & Post-discharge nausea and vomiting (PONV & PDNV)

Pharmacology

5-HT3 receptor antagonist
Binding affinity for serotonin receptor
Influence on vomiting reflex
Pharmacokinetics: linear dose-proportional
Volume of distribution
Metabolism and excretion

Dosage & Administration

Usual dosage for adults
Dosage for chemotherapy-induced nausea and vomiting
Dosage for radiotherapy-induced nausea and vomiting
Dosage for post-operative nausea and vomiting
Dosage for children

Interaction

Safety with corticosteroids, analgesics, antiemetics/antinauseants, antispasmodics, anticholinergic agents
No inhibition of antitumor activity
No significant pharmacokinetic interactions
Low potential for clinically significant drug interactions

Contraindications

Hypersensitivity to the drug or its components

Side Effects

Headaches
Constipation

Pregnancy & Lactation

Pregnancy category 'B'
Excretion in breast milk unknown

Use in Special Populations

No dosage adjustment in elderly patients >65 years of age
Dosage for children (1 month to 10 years)
No dosage adjustment in patients with renal and hepatic dysfunction

Overdose Effects

No known antidote
Supportive care for management of overdose

Therapeutic Class

Anti-emetic drugs

Storage Conditions

Cool & dry place
Protected from light

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