Tegretol 100 mg/5 ml (Oral Suspension)

100 ml bottle: ৳ 379.00

Medicine Details

Category	Details
Generic	Carbamazepine
Company	Novartis bangladesh ltd
Also available as	Tegretol 200 mg tablet Tegretol cr 200 mg tablet

Indications

Partial and secondary generalized tonic-clonic seizures
Primary generalized tonic-clonic seizures
Trigeminal neuralgia
Prophylaxis of bipolar disorder

Pharmacology

Carbamazepine depresses activity in the nucleus ventralis of the thalamus, reduces synaptic propagation of excitatory impulses or decreases summation of temporal stimulation leading to neural discharge by limiting influx of Na ions across cell membrane or other unknown mechanisms. It stimulates the release of antidiuretic hormone (ADH) and potentiates its action in promoting reabsorption of water.

Dosage & Administration

Initial dosage for adults and children over 12 years of age
Dosage for children 12-15 years of age
Dosage for children 6-12 years of age
Dosage for children under 6 years of age
Combination therapy
Trigeminal Neuralgia dosage
Combination therapy

Interaction

Galactorrhoea has been reported in few women on oral contraceptives within the first two months of Tegretol treatment. Hepatic enzyme inducers such as Tegretol and Phenytoin may interact with Tegretol by increasing its metabolism, requiring an increase in dosage of Tegretol.

Contraindications

Problems with the electrical message pathways in the heart (atrioventricular block)
History of decreased blood cell production by the bone marrow (bone marrow depression)
Hereditary blood disorders called porphyrias
Allergy to tricyclic antidepressants
People who have taken a monoamine-oxidase inhibitor antidepressant (MAOI) in the last 14 days

Side Effects

Dizziness
Drowsiness
Ataxia
Dry mouth
Abdominal pain
Nausea
Vomiting
Anorexia
Leucopenia
Proteinuria
Bradycardia
Heart failure
Hypotension
Erythematous skin rash
Aplastic anemia
Increased sensitivity to the sun

Pregnancy & Lactation

Pregnancy category D. Carbamazepine and its epoxide metabolite are transferred to breast milk. Decision should be made whether to discontinue nursing or discontinue the drug due to potential serious side effects.

Precautions & Warnings

May cause dizziness and drowsiness
May cause skin reactions
May rarely cause liver problems
Decreases the blood levels of hormonal contraceptives
Should not be stopped suddenly
Caution should be taken in mixed seizures, elderly people, history of heart, kidney, or liver disease, psychotic illness, raised pressure in the eye, history of blood disorders
Previous interrupted Tegretol therapy due to side effects or allergy

Therapeutic Class

Primary anti-epileptic drugs

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.