Tegretol 100 mg/5 ml (Oral Suspension)
Medicine Details
| Category | Details |
|---|---|
| Generic | Carbamazepine |
| Company | Novartis bangladesh ltd |
| Also available as |
Indications
- Partial and secondary generalized tonic-clonic seizures
- Primary generalized tonic-clonic seizures
- Trigeminal neuralgia
- Prophylaxis of bipolar disorder
Pharmacology
Carbamazepine depresses activity in the nucleus ventralis of the thalamus, reduces synaptic propagation of excitatory impulses or decreases summation of temporal stimulation leading to neural discharge by limiting influx of Na ions across cell membrane or other unknown mechanisms. It stimulates the release of antidiuretic hormone (ADH) and potentiates its action in promoting reabsorption of water.
Dosage & Administration
- Initial dosage for adults and children over 12 years of age
- Dosage for children 12-15 years of age
- Dosage for children 6-12 years of age
- Dosage for children under 6 years of age
- Combination therapy
- Trigeminal Neuralgia dosage
- Combination therapy
Interaction
Galactorrhoea has been reported in few women on oral contraceptives within the first two months of Tegretol treatment. Hepatic enzyme inducers such as Tegretol and Phenytoin may interact with Tegretol by increasing its metabolism, requiring an increase in dosage of Tegretol.
Contraindications
- Problems with the electrical message pathways in the heart (atrioventricular block)
- History of decreased blood cell production by the bone marrow (bone marrow depression)
- Hereditary blood disorders called porphyrias
- Allergy to tricyclic antidepressants
- People who have taken a monoamine-oxidase inhibitor antidepressant (MAOI) in the last 14 days
Side Effects
- Dizziness
- Drowsiness
- Ataxia
- Dry mouth
- Abdominal pain
- Nausea
- Vomiting
- Anorexia
- Leucopenia
- Proteinuria
- Bradycardia
- Heart failure
- Hypotension
- Erythematous skin rash
- Aplastic anemia
- Increased sensitivity to the sun
Pregnancy & Lactation
Pregnancy category D. Carbamazepine and its epoxide metabolite are transferred to breast milk. Decision should be made whether to discontinue nursing or discontinue the drug due to potential serious side effects.
Precautions & Warnings
- May cause dizziness and drowsiness
- May cause skin reactions
- May rarely cause liver problems
- Decreases the blood levels of hormonal contraceptives
- Should not be stopped suddenly
- Caution should be taken in mixed seizures, elderly people, history of heart, kidney, or liver disease, psychotic illness, raised pressure in the eye, history of blood disorders
- Previous interrupted Tegretol therapy due to side effects or allergy
Therapeutic Class
Primary anti-epileptic drugs
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.