Arotril 0.5 mg (Tablet)

Indications

• Treatment of panic disorder
• Treatment of panic disorder with agoraphobia
• Treatment of Lennox-Gastaut Syndrome
• Treatment of akinetic and myoclonic seizures
• Treatment of absence seizures
• Long-term use effectiveness

Pharmacology

• Anticonvulsive effects
• Sedative effects
• Muscle relaxing effects
• Anxiolytic effects
• Enhancement of GABAergic neurotransmission
• Effect on serotonin
• Suppression of paroxysmal activity
• Beneficial effects in generalized and focal epilepsies

Dosage & Administration

• Initial dosage for adults with seizure disorders
• Maximum recommended daily dose for adults
• Initial dose for adults with panic disorder
• Dosage for pediatric patients
• Dosage for infants and children
• Dosage for injection in infants, children, and adults

Interaction

• Presumed lack of alteration of pharmacokinetics of phenytoin, carbamazepine, and phenobarbital
• Unknown effect on the metabolism of other drugs

Contraindications

• Hypersensitivity to benzodiazepines
• Clinical or biochemical evidence of significant liver disease
• Acute narrow angle glaucoma

Side Effects

• CNS depression
• Drowsiness
• Ataxia
• Behavior problems
• Abnormal eye movements
• Aphonia
• Coma
• Tremor
• Vertigo
• Confusion
• Depression
• Amnesia
• Hallucinations
• Increased libido
• Insomnia
• Psychosis
• Palpitations

Pregnancy & Lactation

• Potential for producing congenital malformations
• Risk-benefit assessment for pregnant women
• Adverse effects during pregnancy and labor
• Passage into maternal milk in small amounts
• Compelling indication for administration
• Discontinuation of breastfeeding if undergoing treatment

Precautions & Warnings

• Increased incidence of generalized tonic-clonic seizures
• Concomitant use of valproic acid and Arotril
• Caution in patients with multiple seizure disorders

Use in Special Populations

• Increased production of saliva and bronchial secretion in infants and small children
• Greater pharmacologic effects in elderly patients
• Effect of renal impairment on pharmacokinetics
• Differences in plasma protein binding in cirrhotic patients

Overdose Effects

• Common symptoms of overdose
• Life-threatening effects when taken with other depressants
• Treatment options for overdose

Therapeutic Class

• Adjunct anti-epileptic drugs
• Benzodiazepine hypnotics

Reconstitution

• Instructions for slow intravenous injection
• Instructions for intravenous infusion
• Stability of diluting media
• Precautions for PVC infusion bags
• Caution for using sodium bicarbonate solution

Storage Conditions

• Dry place away from light and heat
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C15H10ClN3O3
• Chemical Structure Image

Common Questions

• Use as a sleeping pill
• Duration of use
• Withdrawal symptoms upon discontinuation
• Early symptoms of suicidal thoughts and actions
• Effect on weight gain
• Effect on memory
• Harmful effects of higher doses
• Potential interactions with other drugs

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