Epnil 0.5 mg (Tablet)
Unit Price: ৳ 8.00 (5 x 10: ৳ 400.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clonazepam |
| Company | Sandoz a novartis division |
| Also available as |
Indications
- Treatment of panic disorder
- Treatment of agoraphobia
- Treatment of Lennox-Gastaut Syndrome
- Treatment of petit mal variant
- Treatment of akinetic seizures
- Treatment of myoclonic seizures
- Adjunct in the treatment of seizures
- Long-term use evaluation
- Effectiveness in controlled clinical trials
- Physician's reevaluation
Pharmacology
- Anticonvulsive effects
- Sedative effects
- Muscle relaxing effects
- Anxiolytic effects
- GABAergic neurotransmission enhancement
- Positive allosteric modulation
- Effect on serotonin
- Suppression of paroxysmal activity
- EEG abnormalities suppression
- Beneficial effects in generalized and focal epilepsies
Dosage & Administration
- Initial dose for adults with seizure disorders
- Increase in dosage increments
- Maximum recommended daily dose
- Initial dose for adults with panic disorder
- Initial dose for pediatric patients
- Dosage for infants and children
- Dosage for infants and children by IV
- Dosage for adults by IV
- Dosage repetition
- Rate of IV injection
Interaction
- Effect on phenytoin metabolism
- Effect on carbamazepine metabolism
- Effect on phenobarbital metabolism
- Uninvestigated effect on other drugs metabolism
Contraindications
- Hypersensitivity to benzodiazepines
- Clinical evidence of liver disease
- Biochemical evidence of liver disease
- Open angle glaucoma
- Acute narrow angle glaucoma
Side Effects
- CNS depression
- Drowsiness
- Ataxia
- Behavior problems
- Abnormal eye movements
- Aphonia
- Coma
- Tremor
- Vertigo
- Confusion
Pregnancy & Lactation
- Possibility of producing congenital malformations
- Evidence of anticonvulsant drugs as teratogens
- Administration during pregnancy
- High doses effects in the last trimester
- Effects on the unborn child
- Exacerbation of epilepsy
- Withdrawal symptoms in newborn infants
- Passage into maternal milk
- Discontinuation of breastfeeding
Precautions & Warnings
- Increase in incidence of generalized tonic-clonic seizures
- Use with valproic acid
- Production of saliva and bronchial secretion in infants and small children
- Greater pharmacologic effects in elderly patients
- No dose adjustment required for renal impairment
- Plasma protein binding in cirrhotic patients
- Clearance reduction in liver cirrhosis
Use in Special Populations
- Increased production of saliva and bronchial secretion in infants and small children
- Greater pharmacologic effects in elderly patients
- No dose adjustment required for renal impairment
- Plasma protein binding in cirrhotic patients
Overdose Effects
- Common symptoms
- Drowsiness
- Ataxia
- Dysarthria
- Nystagmus
- Areflexia
- Apnoea
- Hypotension
- Cardiorespiratory depression
- Coma
- Seizure recurrence
Therapeutic Class
- Adjunct anti-epileptic drugs
- Benzodiazepine hypnotics
Reconstitution
- Preparation for IV administration
- Dilution with water for injection
- Monitoring of EEG, respiration and blood pressure
- Dilution for IV infusion
- Stability of diluting media
- Preparation using infusion bags other than PVC
Storage Conditions
- Dry place
- Protection from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula : C15H10ClN3O3
- Chemical Structure Image
Common Questions about Epnil 0.5 mg Tablet
- Use as a sleeping pill
- Duration of use
- Withdrawal symptoms
- Early symptoms of suicidal thoughts
- Effect on weight
- Effect on memory
- Harmful effects of overdose
- Combination with other medications
- Quick Tips