Lonapam 2 mg (Tablet)

Unit Price: ৳ 7.00 (5 x 10: ৳ 350.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Clonazepam
Company Delta pharma ltd
Also available as
Lonapam 05 mg tablet Lonapam 1 mg tablet

Title

  • Lonapam 2mg Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

Lonapam 2mg Tablet is indicated for the treatment of panic disorder, with or without agoraphobia, as well as for the treatment of Lennox-Gastaut Syndrome, akinetic and myoclonic seizures. It exhibits anticonvulsive, sedative, muscle relaxing, and anxiolytic effects and enhances GABAergic neurotransmission at inhibitory synapses. The recommended dosage varies for adults and pediatric patients and can be administered orally or through injection. Lonapam interacts with various other drugs and has contraindications, side effects, and precautions to be aware of. It should be stored in a dry place away from light and heat.

Indications

Treatment of panic disorder, with or without agoraphobia, and adjunct in the treatment of the Lennox-Gastaut Syndrome (petit mal variant), akinetic and myoclonic seizures

Pharmacology

  • Anticonvulsive effects
  • Sedative effects
  • Muscle relaxing effects
  • Anxiolytic effects
  • Enhancement of GABAergic neurotransmission
  • Effect on serotonin
  • Effects in generalized and focal epilepsies

Dosage and administration

  • Oral:
    • Adults:
      • Initial dose not to exceed 1.5 mg/day
      • Dosage increment of 0.5 to 1 mg every 3 days
      • Maximum recommended daily dose 20 mg
    • Panic disorder: Initial dose of 0.25 mg for adults
  • Injection:
    • Infants and children: Half of a vial (0.5 mg)
    • Adults: 1 vial (1 mg)

Interaction

Does not appear to alter the pharmacokinetics of specific drugs, but its effect on the metabolism of other drugs has not been investigated

Contraindications

  • Hypersensitivity to benzodiazepines
  • Significant liver disease
  • Acute narrow angle glaucoma

Side effects

  • CNS depression
  • Drowsiness
  • Ataxia
  • Behavior problems
  • Abnormal eye movements
  • Aphonia
  • Coma
  • Tremor
  • Vertigo
  • Confusion
  • Depression
  • Amnesia
  • Hallucinations
  • Increased libido
  • Insomnia
  • Psychosis
  • Palpitations

Pregnancy and lactation

  • Pregnancy: Administered only if potential benefits outweigh the risk to the fetus
  • Lactation: Mothers undergoing treatment should discontinue breastfeeding

Precautions and warnings

May increase the incidence or precipitate the onset of generalized tonic-clonic seizures when used in patients with several different types of seizure disorders coexisting. The concomitant use of valproic acid and Lonapam may produce absence status

Special populations

  • Pediatric use: May cause increased production of saliva and bronchial secretion in infants and small children
  • Geriatric use: Benzodiazepine pharmacologic effects appear to be greater in elderly patients
  • Renal impairment: Does not affect the pharmacokinetics of Lonapam
  • Hepatic impairment: Plasma protein binding in cirrhotic patients is significantly different from that in healthy subjects

Overdose effects

  • Symptoms: Drowsiness, ataxia, dysarthria, nystagmus, areflexia, apnoea, hypotension, cardiorespiratory depression, coma
  • Treatment:
    • Monitor vital signs
    • Institute supportive measures
    • Prevent further absorption using appropriate methods
    • Consider the use of flumazenil

Therapeutic class

  • Adjunct anti-epileptic drugs
  • Benzodiazepine hypnotics

Reconstitution

  • Slow intravenous injection: Dilute with 1 ml of water for injection prior to administration
  • Intravenous infusion: Can be diluted for infusion with various diluting media
  • Intramuscular injection: Should be used only in exceptional cases

Storage conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical structure

  • Molecular formula: C15H10ClN3O3
  • Chemical structure image: https://medex.com.bd/storage/res/g-res-284-clonazepam-chemical-structure-S6GmKrvYS03ZYjOTAtig.svg

Common questions

  • Sleeping pill: Not used as a sleeping pill
  • Long term use: Use as long as advised by the doctor
  • Withdrawal symptoms: Difficulty in sleeping, changes in mood, increased sweating, muscle pain, headache, shaking, feeling restless, anxious, tense, etc.
  • Suicidal thoughts: Pay attention to changes in body and consult the doctor regularly
  • Weight gain: Might cause weight gain and weight loss
  • Memory: Does not affect memory
  • Overdose effects: Can cause sleepiness, change in speech, confusion, abnormalities in eye movement, etc.
  • Interactions with other medications: Avoid combination with specific drugs

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