Myotril 0.5 mg (Tablet)
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clonazepam |
| Company | Ibn sina pharmaceuticals ltd |
Indications
- Treatment of panic disorder with or without agoraphobia
- Adjunct in the treatment of Lennox-Gastaut Syndrome
- Treatment of akinetic and myoclonic seizures
- Treatment of absence seizures (petit mal) resistant to succinimides
Pharmacology
- Anticonvulsive effects
- Sedative effects
- Muscle relaxing effects
- Anxiolytic effects
- Enhancement of GABAergic neurotransmission
- Enhanced action of released GABA on postsynaptic transmembrane chloride ion flux
- Effects on serotonin
- Suppression of paroxysmal activity in various types of seizures
Dosage & Administration
- Initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses
- Initial dose for adults with panic disorder is 0.25 mg given in two divided doses
- Dosage may be increased in increments of 0.5 to 1 mg every 3 days
- Maintenance dosage must be individualized for each patient
- Maximum recommended daily dose is 20 mg
- Pediatric patients initial dose should be between 0.01 and 0.03 mg/kg/day
- Injection dosage for infants, children, and adults
Interaction
- No apparent alteration of the pharmacokinetics of certain drugs
- Effect on the metabolism of other drugs not investigated
Contraindications
- History of hypersensitivity to benzodiazepines
- Clinical or biochemical evidence of significant liver disease
- Contradicted in acute narrow angle glaucoma
Side Effects
- Frequently occurring CNS depression
- Drowsiness
- Ataxia
- Behavior problems
- Abnormal eye movements
- Aphonia
- Coma
- Tremor
- Vertigo
- Confusion
- Depression
- Amnesia
- Hallucinations
- Hysteria
- Increased libido
- Insomnia
- Psychosis
- Palpitations
Pregnancy & Lactation
- Potential for producing congenital malformations
- Evidence of anticonvulsants acting as teratogens
- Administered to pregnant women only if benefits outweigh the risk to the fetus
- Possible irregularities in the heartbeat of the unborn child with high doses
- Active ingredient passes into maternal milk in small amounts
- Breastfeeding to be discontinued if there is a compelling indication to administer the drug
Precautions & Warnings
- Increased incidence or precipitation of generalized tonic-clonic seizures in certain patients
- Concomitant use with valproic acid may produce absence status
Use in Special Populations
- Causes increased production of saliva and bronchial secretion in infants and small children
- Benzodiazepine pharmacologic effects appear to be greater in elderly patients
- Renal impairment does not affect the pharmacokinetics
- Influence of hepatic impairment on pharmacokinetics not fully investigated
Overdose Effects
- Symptoms such as drowsiness, ataxia, dysarthria, nystagmus
- Rarely life-threatening when taken alone
- Potential for areflexia, apnoea, hypotension, cardiorespiratory depression, coma
- Increased frequency of seizures may occur at supratherapeutic plasma concentrations
Therapeutic Class
- Adjunct anti-epileptic drugs
- Benzodiazepine hypnotics
Reconstitution
- Preparation details for slow intravenous injection
- Preparation details for intravenous infusion
- Preparation details for intramuscular injection
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C15H10ClN3O3
Common Questions about Myotril 0.5 mg Tablet
- Usage not as a sleeping pill
- Not recommended for longer-term use without doctor's advice
- Possible withdrawal symptoms upon stopping
- Need for monitoring early symptoms of suicidal thoughts and actions
- Potential for weight gain or weight loss as side effects
- No significant impact on memory
- Possible harmful effects of overdose
- Recommendations for safe usage and precautions