Pase 2.5 mg/ml (Pediatric Drops)
10 ml drop: ৳ 80.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Clonazepam |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Treatment of panic disorder with or without agoraphobia
- Treatment of Lennox-Gastaut Syndrome
- Treatment of akinetic and myoclonic seizures
- Adjunct in the treatment of petit mal variant of the Lennox-Gastaut Syndrome
- Treatment of absence seizures (petit mal)
Pharmacology
- Exhibits anticonvulsive, sedative, muscle relaxing, and anxiolytic effects
- Enhances GABAergic neurotransmission at inhibitory synapses
- Suppresses various types of paroxysmal activity including seizures
Dosage & Administration
- Initial adult dose for seizure disorders: 1.5 mg/day divided into three doses
- Maximum recommended daily dose for seizures: 20 mg
- Initial adult dose for panic disorder: 0.25 mg given in two divided doses
- Maximum target dose for panic disorder: 1 mg/day
Interaction
- Does not appear to alter the pharmacokinetics of certain drugs
Contraindications
- Hypersensitivity to benzodiazepines
- Clinical or biochemical evidence of significant liver disease
- Acute narrow angle glaucoma
- Not to be used in pregnancy or lactation
Side Effects
- CNS depression
- Drowsiness
- Ataxia
- Behavior problems
- Abnormal eye movements
- Tremor
- Vertigo
- Depression
- Amnesia
- Hallucinations
- Psychosis
- Palpitations
Pregnancy & Lactation
- Potential teratogenic effects
- Drug should only be administered if potential benefits outweigh the risk to the fetus
- Active ingredient may pass into maternal milk
Precautions & Warnings
- May increase the incidence of generalized tonic-clonic seizures
- Concomitant use with valproic acid may produce absence status
Use in Special Populations
- In infants and small children, may cause increased production of saliva and bronchial secretion
- Benzodiazepine pharmacologic effects appear to be greater in elderly and renal impairment patients
Overdose Effects
- Symptoms: drowsiness, ataxia, dysarthria, nystagmus
- Treatment: monitor vital signs, institute supportive measures, prevent further absorption, consider use of flumazenil
Therapeutic Class
- Adjunct anti-epileptic drugs
- Benzodiazepine hypnotics
Reconstitution
- Preparation for slow intravenous injection
- Preparation for intravenous infusion
- Intramuscular injection only in exceptional cases
Storage Conditions
- Keep in a dry place away from light and heat
Chemical Structure
- Molecular Formula: C15H10ClN3O3
- Chemical Structure Image URL: https://medex.com.bd/storage/res/g-res-284-clonazepam-chemical-structure-S6GmKrvYS03ZYjOTAtig.svg