Xetril 2 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clonazepam |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Title
Xetril 2 mg Tablet
Categories
- Medicine
- Pharmaceuticals
- Anti-Epileptic
- Anxiolytic
Description
Xetril 2 mg Tablet is indicated for the treatment of panic disorder, with or without agoraphobia, as well as an adjunct in the treatment of the Lennox-Gastaut Syndrome, akinetic and myoclonic seizures. It exhibits pharmacological properties common to benzodiazepines, including anticonvulsive, sedative, muscle relaxing, and anxiolytic effects. Dosage varies for adults and pediatric patients with specific instructions for oral and injection administration. It is contraindicated in patients with a history of hypersensitivity to benzodiazepines and those with clinical or biochemical evidence of significant liver disease. Common side effects include CNS depression, drowsiness, ataxia, and behavior problems. Pregnancy and lactation precautions are advised due to the possibility of producing congenital malformations. Precautions should be taken in patients with multiple seizure disorders and concomitant use of valproic acid. Storage conditions involve keeping the product in a dry place away from light and heat, and out of the reach of children. It is classified under the therapeutic class of adjunct anti-epileptic drugs and benzodiazepine hypnotics.
Attributes
- Indications:
- Treatment of panic disorder
- Adjunct in the treatment of Lennox-Gastaut Syndrome
- Akinetic and myoclonic seizures
- Pharmacological Properties:
- Anticonvulsive effects
- Sedative effects
- Muscle relaxing effects
- Anxiolytic effects
- Enhancement of GABAergic neurotransmission
- Effect on serotonin
- Suppression of paroxysmal activity including spike and wave discharge in absences seizures
- Beneficial effects in generalized and focal epilepsies
- Dosage & Administration:
- Initial adult dose for seizure disorders
- Maximum recommended daily dose
- Initial adult dose for panic disorder
- Pediatric patient dosage
- Injection dosage for infants, children, and adults
- Interaction:
- No alteration of pharmacokinetics of phenytoin, carbamazepine, or phenobarbital
- Effect on the metabolism of other drugs not investigated
- Contraindications:
- Hypersensitivity to benzodiazepines
- Clinical or biochemical evidence of significant liver disease
- Acute narrow angle glaucoma
- Side Effects:
- CNS depression
- Drowsiness
- Ataxia
- Behavior problems
- Abnormal eye movements
- Aphonia
- Coma
- Tremor
- Confusion
- Depression
- Amnesia
- Hallucinations
- Psychosis
- Palpitations
- Pregnancy & Lactation:
- Potential for producing congenital malformations
- Administration only if potential benefits outweigh risk
- Possibility of withdrawal symptoms in newborn infants
- Transfer into maternal milk in small amounts
- Nursing mothers should discontinue breastfeeding if compelling indication exists
- Precautions & Warnings:
- Possible increase in the incidence or onset of generalized tonic-clonic seizures
- Concomitant use with valproic acid may produce absence status
- Use in Special Populations:
- Increased production of saliva and bronchial secretion in infants and small children
- Greater pharmacologic effects in elderly patients
- No dose adjustment in patients with renal impairment
- Plasma protein binding in hepatic impairment different from healthy subjects
- Overdose Effects:
- Symptoms including drowsiness, ataxia, dysarthria, nystagmus
- Potentially life-threatening effects if drug is taken alone
- Increased frequency of seizures at supratherapeutic plasma concentrations
- Respiratory depressant effects more serious in patients with respiratory disease
- Therapeutic Class:
- Adjunct anti-epileptic drugs
- Benzodiazepine hypnotics
- Reconstitution:
- Instructions for slow intravenous injection
- Instructions for intravenous infusion
- Not advised for intramuscular injection
- Storage Conditions:
- Keep in a dry place away from light and heat
- Keep out of the reach of children
- Chemical Structure:
- Molecular formula: C15H10ClN3O3
- Chemical Structure image available
- Common Questions:
- Sleeping pill usage
- Long-term usage
- Withdrawal symptoms
- Early symptoms of suicidal thoughts and actions
- Effect on weight gain
- Effect on memory
- Harmful effects of overdose
- Possible combinations with other medications
- Quick tips for usage