Fosfen 150 mg/2 ml (Injection)

Title and Category

• Fosphenytoin Sodium Injection
• Anti-epileptic
• Adjunct therapeutic class
• Pharmaceutical product

Indications

• Control of generalized convulsive status epilepticus
• Prevention and treatment of seizures during neurosurgery or head injury
• Substitution for oral Phenytoin
• Short-term parenteral administration

Pharmacology

• Pro-drug intended for parenteral administration
• Active metabolite is Phenytoin
• Supplied in ampoule as a ready-mixed solution
• Buffer adjusted to pH 8.6 to 9.0

Dosage and Administration

• Expressed as Phenytoin Sodium equivalents
• Dose, concentration, and infusion rates for IV administration
• Dilution in 5% Dextrose or 0.9% Saline solution
• Dosage adjustment for patients with renal or hepatic disease
• Different dosing regimes for status epilepticus and prophylaxis

Interaction

• Drugs that may increase plasma Phenytoin concentrations
• Drugs that may decrease plasma Phenytoin concentrations
• Effects of Phenytoin on other drug plasma concentrations

Contraindications

• Hypersensitivity to Fosphenytoin or its ingredients
• Sinus bradycardia, sino-atrial block, A-V block, and Adams-Stokes syndrome

Side Effects

• Cardiovascular collapse and central nervous system depression
• Potential adverse events including nystagmus, dizziness, pruritus, etc.
• Safety advice for intravenous infusion

Pregnancy and Lactation

• Pregnancy Category D
• Contraindicated during pregnancy
• Not recommended for breastfeeding women

Precautions and Warnings

• Doses expressed as Phenytoin Sodium equivalents
• Warnings for status epilepticus dosing regime
• Caution in patients with hypotension and severe myocardial insufficiency
• Discontinuation and substitution precautions
• Consideration for patients with severe renal impairment

Overdose Effects

• Nausea, vomiting, lethargy, tachycardia, bradycardia
• Treatment and supportive measures for overdose
• Observation of respiratory and circulatory systems

Therapeutic Class

• Adjunct anti-epileptic drugs

Storage Conditions

• Refrigeration at 2°C to 8°C
• Avoid deep freeze and prolonged room temperature storage
• Particulate matter indication
• Child-resistant packaging

Related Brands