Lamitrin 25 mg (Tablet)
Unit Price: ৳ 10.03 (3 x 10: ৳ 300.90)
Strip Price: ৳ 100.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Lamotrigine |
| Company | Aci limited |
| Also available as |
Indications
- Adjunctive therapy for partial-onset seizures
- Adjunctive therapy for primary generalized tonic-clonic seizures
- Adjunctive therapy for generalized seizures of Lennox-Gastaut syndrome
- Monotherapy for epilepsy in patients aged 16 years and older
- Treatment for bipolar disorder in patients aged 18 years and older
Description
- Phenyltriazine antiepileptic medication
- Used to control epileptic seizures
- Also used to treat some types of bipolar disorder
- Inhibits voltage-sensitive sodium channels
- Stabilizes neuronal membranes
- Inhibits presynaptic excitatory neurotransmitter release
Pharmacology
- Inhibition of voltage-sensitive sodium channels
- Modulation of release of presynaptic excitatory neurotransmitters
- Binding properties to various receptors
- Weak inhibitory effects on serotonin 5-HT3 receptors
- Weak binding to adenosine, adrenergic, dopamine, GABA, histamine, opioid, mACh, and serotonin 5-HT2 receptors
- Inhibition of Cav2.3 (R-type) calcium currents
Dosage & Administration
- Different escalation regimens for patients with epilepsy aged 2 years and older
- Escalation regimen for monotherapy in patients aged 16 years and older
- Dosage adjustments based on concomitant medication use
- Specific weight-based dosing guide for pediatric patients with epilepsy
- Escalation regimen for adults with bipolar disorder
Interaction
- Increased concentrations with valproate
- Decreased concentrations with carbamazepine, phenytoin, phenobarbital, primidone, and rifampin
- Decreased concentrations with estrogen-containing oral contraceptives
- Decreased exposure with protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir
Side Effects
- Dizziness
- Headache
- Diplopia
- Nausea
- Blurred vision
- Rash
- Vomiting in children
- Diarrhea in children
- Infection in children
- Fever in children
- Abdominal pain in children
- Tremor in children
Pregnancy & Lactation
- Pregnancy Category C
- Excretion in human milk
- Potential for serious adverse reactions in nursing infants
Precautions & Warnings
- Discontinue at the first sign of rash
- Monitor for blood dyscrasias
- Monitor for suicidal thoughts or behaviors
- Monitor for signs of aseptic meningitis
Use in Special Populations
- Limited safety and effectiveness in very young pediatric patients with epilepsy
- Limited safety and effectiveness in pediatric patients aged 10 to 17 years with bipolar disorder
Overdose Effects
- Ataxia
- Nystagmus
- Seizures
- Decreased level of consciousness
- Coma
- Intraventricular conduction delay
Therapeutic Class
- Primary anti-epileptic drugs
Storage Conditions
- Keep out of reach of children
- Store in a dry place
- Store below 25°C temperature
- Store protected from light