Lameptil 25 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Lamotrigine |
| Company | Sandoz a novartis division |
| Also available as |
Indications
- Adjunctive therapy for partial-onset seizures
- Adjunctive therapy for primary generalized tonic-clonic seizures
- Adjunctive therapy for generalized seizures of Lennox-Gastaut syndrome
- Monotherapy for epilepsy in patients aged 16 years and older
- Treatment for bipolar disorder in patients aged 18 years and older
Description
- Phenyltriazine antiepileptic
- Treats some types of epilepsy
- Controls epileptic seizures
- Inhibits voltage-sensitive sodium channels
- Stabilizes neuronal membranes
- Inhibits presynaptic excitatory neurotransmitter release
Pharmacology
- Mechanism of action not fully elucidated
- Chemically unrelated to phenytoin and carbamazepine
- Resembles actions of phenytoin and carbamazepine
- Inhibition of sodium channels
- Suppression of glutamate release
- Binding properties to various receptors
- Weak effects on serotonin, adrenergic, dopamine, GABA, histamine, opioid, mACh, and sigma receptors
- Clinical benefit in neuropathic pain states
Dosage & Administration
- Escalation regimen for lamotrigine in patients older than 12 years with epilepsy
- Escalation regimen for lamotrigine in patients aged 2 to 12 years with epilepsy
- Escalation regimen for lamotrigine in adults with bipolar disorder
- Initial weight-based dosing guide for patients aged 2 to 12 years taking valproate with epilepsy
Interaction
- Valproate increases Lamotil concentrations by more than 2-fold
- Carbamazepine, phenytoin, phenobarbital, primidone, and rifampin decrease Lamotil concentrations by approximately 40%
- Estrogen-containing oral contraceptives decrease Lamotil concentrations by approximately 50%
- Protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir decrease Lamotil exposure
Side Effects
- Dizziness
- Headache
- Diplopia
- Ataxia
- Nausea
- Blurred vision
- Somnolence
- Pharyngitis
- Rash
- Vomiting in children
- Diarrhea in children
- Infection in children
- Fever in children
- Abdominal pain in children
- Tremor in children
Pregnancy & Lactation
- Pregnancy Category C
- Excretion in human milk
- Potential for serious adverse reactions in nursing infants
- Consideration for discontinuation of nursing or drug
Precautions & Warnings
- Discontinue at the first sign of rash
- Blood dyscrasias may occur
- Monitor for signs of anemia, infection, or bleeding
- Monitor for suicidal thoughts or behaviors
- Monitor for signs of meningitis
Use in Special Populations
- Safety and effectiveness not demonstrated in very young pediatric patients aged 1 to 24 months for epilepsy
- Safety and effectiveness not established in pediatric patients aged 10 to 17 years for bipolar disorder
Overdose Effects
- Ataxia
- Nystagmus
- Seizures
- Decreased level of consciousness
- Coma
- Intraventricular conduction delay
Therapeutic Class
- Primary anti-epileptic drugs
Storage Conditions
- Keep out of reach of children
- Store in a dry place
- Below 25°C temperature
- Protected from light