Lameptil 50 mg (Tablet)
Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Lamotrigine |
| Company | Sandoz a novartis division |
| Also available as |
Title and Categories
- Lameptil Antiepileptic Drug
- Phenyltriazine Antiepileptic
- Primary Anti-epileptic Drugs
Indications
- Adjunctive therapy for partial-onset seizures
- Adjunctive therapy for primary generalized tonic-clonic seizures
- Adjunctive therapy for generalized seizures of Lennox-Gastaut syndrome
- Monotherapy for epilepsy in patients aged 16 years and older
- Treatment for bipolar disorder in patients aged 18 years and older
Functions
- Controls epileptic seizures
- Inhibits voltage-sensitive sodium channels
- Stabilizes neuronal membranes
- Inhibits presynaptic excitatory neurotransmitter release
- Modulates release of presynaptic excitatory neurotransmitters
Dosage & Administration
- Different dosage regimens based on age and concomitant drug use
Interaction
- Valproate increases Lameptil concentrations by more than 2-fold
- Carbamazepine, phenytoin, phenobarbital, primidone, and rifampin decrease Lameptil concentrations by approximately 40%
- Estrogen-containing oral contraceptives decrease Lameptil concentrations by approximately 50%
- Protease inhibitors such as lopinavir/ritonavir and atazanavir/ritonavir decrease Lameptil exposure by approximately 50% and 32% respectively
Side Effects
- Adult: Dizziness, headache, diplopia, ataxia, nausea, blurred vision, somnolence, pharyngitis, rash
- Children: Vomiting, diarrhea, infection, fever, abdominal pain, tremor
Pregnancy & Lactation
- Pregnancy Category C
- Excreted in human milk
- Potential for serious adverse reactions in nursing infants
- Decision should be made whether to discontinue nursing or discontinue the drug, considering the importance of the drug to the mother
Precautions & Warnings
- Discontinue at the first sign of rash
- Blood dyscrasias such as neutropenia, thrombocytopenia, pancytopenia may occur
- Monitor for signs of anemia, unexpected infection, or bleeding
- Monitor for suicidal thoughts or behaviors
- Monitor for signs of meningitis
Use in Special Populations
- Safety and effectiveness not demonstrated in very young pediatric patients aged 1 to 24 months
- Safety and effectiveness not established in pediatric patients aged 10 to 17 years
Overdose Effects
- Ataxia, nystagmus, seizures, decreased level of consciousness, coma, intraventricular conduction delay
Pharmacology
- Exact mechanism of action not fully elucidated
- Actions resemble those of phenytoin and carbamazepine
- Likely inhibits sodium currents by selective binding to the inactive sodium channel
- Displays binding properties to several different receptors
- Weak inhibitory effects observed at various receptors
- Inhibits Cav2.3 (R-type) calcium currents
Drug Classes
- Phenyltriazine Antiepileptic
- Primary Anti-epileptic Drugs
Storage Conditions
- Keep out of reach of children
- Store in a dry place
- Below 25°C temperature
- Protected from light