Iracet 500 mg/5 ml (IV Infusion)
5 ml ampoule: ৳ 40.13 (3 x 2: ৳ 240.78)
Medicine Details
| Category | Details |
|---|---|
| Generic | Levetiracetam |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Monotherapy for partial-onset seizures in adults and adolescents
- Adjunctive therapy for partial-onset seizures in adults, adolescents, children, and infants
- Treatment of myoclonic seizures in adults and adolescents with Juvenile Myoclonic Epilepsy
- Treatment of primary generalized tonic-clonic seizures in adults and adolescents with Idiopathic Generalised Epilepsy
Description
- Precise mechanism of antiepileptic effect is unknown
- Minimal activity in submaximal stimulation and threshold tests
- Protection against secondarily generalized activity from focal seizures induced by pilocarpine and kainic acid
- Inhibition of burst firing without affecting normal neuronal excitability
Dosage
- Recommended starting dose for adults and adolescents from 16 years is 250 mg twice daily
- Initial therapeutic dose of 500 mg twice daily after two weeks
- Maximum dose is 1500 mg twice daily for adults and adolescents
Administration
- Oral administration with sufficient liquid
- Daily dose is administered in two equally divided doses
Interaction
- No influence on serum concentrations of existing antiepileptic medicinal products
- Inhibition of renal clearance of the primary metabolite by probenecid
- Decrease in methotrexate clearance when co-administered with Iracet
- Reports of decreased efficacy when co-administered with osmotic laxative macrogol
Contraindications
- Hypersensitivity to the active substance or other pyrrolidone derivatives or excipients
Side Effects
- Common adverse reactions include somnolence, asthenia, infection, dizziness in adult patients
- Common adverse reactions include fatigue, aggression, nasal congestion, decreased appetite, irritability in pediatric patients
Pregnancy & Lactation
- Not recommended during pregnancy and in women of childbearing potential not using contraception
- Excretion in human breast milk, breastfeeding not recommended
Precautions & Warnings
- May require dose adjustment in patients with renal impairment
- Rare cases of decreased blood cell counts described at the beginning of treatment
- Increased risk of suicidal thoughts and behavior
- Tablet formulation not adapted for use in infants and children under the age of 6 years
Use in Special Populations
- Adjustment of the dose recommended in elderly patients with compromised renal function
- Individualized daily dose according to renal function in renal impairment
- No dose adjustment needed in patients with mild to moderate hepatic impairment
Overdose Effects
- Symptoms include somnolence, agitation, aggression, depressed level of consciousness, respiratory depression, and coma
- No specific antidote, treatment is symptomatic and may include haemodialysis
Therapeutic Class
- Adjunct anti-epileptic drugs
Storage Conditions
- Store at a cool temperature not exceeding 25°C and dry place, protected from light