Iracet 500 mg/5 ml (IV Infusion)

5 ml ampoule: ৳ 40.13 (3 x 2: ৳ 240.78)

Medicine Details

Category Details
Generic Levetiracetam
Company Square pharmaceuticals plc
Also available as
Iracet 250 mg tablet Iracet 500 mg tablet Iracet 500 mg oral solution Iracet xr 500 mg tablet

Indications

  • Monotherapy for partial-onset seizures in adults and adolescents
  • Adjunctive therapy for partial-onset seizures in adults, adolescents, children, and infants
  • Treatment of myoclonic seizures in adults and adolescents with Juvenile Myoclonic Epilepsy
  • Treatment of primary generalized tonic-clonic seizures in adults and adolescents with Idiopathic Generalised Epilepsy

Description

  • Precise mechanism of antiepileptic effect is unknown
  • Minimal activity in submaximal stimulation and threshold tests
  • Protection against secondarily generalized activity from focal seizures induced by pilocarpine and kainic acid
  • Inhibition of burst firing without affecting normal neuronal excitability

Dosage

  • Recommended starting dose for adults and adolescents from 16 years is 250 mg twice daily
  • Initial therapeutic dose of 500 mg twice daily after two weeks
  • Maximum dose is 1500 mg twice daily for adults and adolescents

Administration

  • Oral administration with sufficient liquid
  • Daily dose is administered in two equally divided doses

Interaction

  • No influence on serum concentrations of existing antiepileptic medicinal products
  • Inhibition of renal clearance of the primary metabolite by probenecid
  • Decrease in methotrexate clearance when co-administered with Iracet
  • Reports of decreased efficacy when co-administered with osmotic laxative macrogol

Contraindications

  • Hypersensitivity to the active substance or other pyrrolidone derivatives or excipients

Side Effects

  • Common adverse reactions include somnolence, asthenia, infection, dizziness in adult patients
  • Common adverse reactions include fatigue, aggression, nasal congestion, decreased appetite, irritability in pediatric patients

Pregnancy & Lactation

  • Not recommended during pregnancy and in women of childbearing potential not using contraception
  • Excretion in human breast milk, breastfeeding not recommended

Precautions & Warnings

  • May require dose adjustment in patients with renal impairment
  • Rare cases of decreased blood cell counts described at the beginning of treatment
  • Increased risk of suicidal thoughts and behavior
  • Tablet formulation not adapted for use in infants and children under the age of 6 years

Use in Special Populations

  • Adjustment of the dose recommended in elderly patients with compromised renal function
  • Individualized daily dose according to renal function in renal impairment
  • No dose adjustment needed in patients with mild to moderate hepatic impairment

Overdose Effects

  • Symptoms include somnolence, agitation, aggression, depressed level of consciousness, respiratory depression, and coma
  • No specific antidote, treatment is symptomatic and may include haemodialysis

Therapeutic Class

  • Adjunct anti-epileptic drugs

Storage Conditions

  • Store at a cool temperature not exceeding 25°C and dry place, protected from light

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