Leveron 500 mg (Tablet)
Unit Price: ৳ 30.09 (5 x 4: ৳ 601.80)
Strip Price: ৳ 120.36
Medicine Details
| Category | Details |
|---|---|
| Generic | Levetiracetam |
| Company | Synovia pharma plc |
| Also available as |
Indications
- Monotherapy in the treatment of partial-onset seizures with or without secondary generalisation in adults and adolescents from 16 years of age with newly diagnosed epilepsy
- Adjunctive therapy for partial-onset seizures with or without secondary generalization in adults, adolescents, children, and infants from 1 month of age with epilepsy
- Treatment of myoclonic seizures in adults and adolescents from 12 years of age with Juvenile Myoclonic Epilepsy
- Treatment of primary generalized tonic-clonic seizures in adults and adolescents from 12 years of age with Idiopathic Generalised Epilepsy
Description
- Precise mechanism(s) by which the medicine exerts its antiepileptic effect is unknown
- Minimal activity in submaximal stimulation and in threshold tests
- Protection against secondarily generalized activity induced by chemo convulsants that mimic features of human complex partial seizures
- Inhibition of burst firing without affecting normal neuronal excitability
- Selective prevention of hyper synchronization of epileptiform burst firing and propagation of seizure activity
Dosage
- Recommended starting dose of 250 mg twice daily for adults and adolescents from 16 years of age
- Initial therapeutic dose of 500 mg twice daily after two weeks
- Maximum dose of 1500 mg twice daily
- Different dosage recommendations for patients based on age, weight, and formulation (tablet or oral solution)
Administration
- Must be taken orally
- Swallowed with sufficient quantity of liquid
- May be taken with or without food
- Administered in two equally divided doses
Interaction
- No influence on serum concentrations of existing antiepileptic medicinal products
- No influence by antiepileptic medicinal products on the pharmacokinetics of the medicine
- Concomitant administration with probenecid and methotrexate
- Isolated reports of decreased efficacy when concomitantly administered with osmotic laxative macrogol
Contraindications
- Hypersensitivity to the active substance or other pyrrolidone derivatives or to any of the excipients
Side Effects
- Common adverse reactions including somnolence, asthenia, infection, dizziness, fatigue, aggression, nasal congestion, decreased appetite, and irritability
Pregnancy & Lactation
- Not recommended during pregnancy and in women of childbearing potential not using contraception unless clinically necessary
- Excreted in human breast milk
- Breastfeeding is not recommended
- No impact on fertility detected in animal studies, potential risk for humans unknown
Precautions & Warnings
- Administration to patients with renal impairment may require dose adjustment
- Rare cases of decreased blood cell counts described
- Suicidal thoughts and behaviour reported in patients treated with anti-epileptic agents
- Tablet formulation not adapted for use in infants and children under the age of 6 years
Use in Special Populations
- Dose adjustment recommended in elderly patients with compromised renal function
- Daily dose must be individualized according to renal function
- No dose adjustment needed in patients with mild to moderate hepatic impairment
Overdose Effects
- Observation of somnolence, agitation, aggression, depressed level of consciousness, respiratory depression, and coma
- No specific antidote available
- Symptomatic treatment recommended
- Possible use of haemodialysis
Therapeutic Class
- Adjunct anti-epileptic drugs
Storage Conditions
- Store at a cool temperature (not exceeding 25°C) and dry place, protected from light