Levipil 500 mg (Tablet)

Unit Price: ৳ 30.00 (3 x 10: ৳ 900.00)

Strip Price: ৳ 300.00

Medicine Details

Category	Details
Generic	Levetiracetam
Company	Sun pharmaceutical bangladesh ltd
Also available as	Levipil 250 mg tablet

Title

Levipil

Description

The precise mechanism(s) by which Levipil exerts its antiepileptic effect is unknown. Levipil showed only minimal activity in submaximal stimulation and in threshold tests. Protection was observed, however, against secondarily generalized activity from focal seizures induced by pilocarpine and kainic acid, two chemo convulsants that induce seizures that mimic some features of human complex partial seizures with secondary generalization. In vitro and in vivo recordings of epileptiform activity from the hippocampus have shown that Levipil inhibits burst firing without affecting normal neuronal excitability, suggesting that Levipil may selectively prevent hyper synchronization of epileptiform burst firing and propagation of seizure activity.

Indications

Partial-onset seizures with or without secondary generalization
Myoclonic seizures in Juvenile Myoclonic Epilepsy
Primary generalized tonic-clonic seizures in Idiopathic Generalised Epilepsy

Dosage

Recommended starting dose is 250 mg twice daily for adults and adolescents from 16 years of age
Maximum dose is 1500 mg twice daily for adults and adolescents
Tablet formulation not adapted for use in infants and children under the age of 6 years

Administration

Orally administered in two equally divided doses
Can be taken with or without food

Interaction

Did not influence the serum concentrations of existing antiepileptic medicinal products
Probenecid may inhibit the renal clearance of the primary metabolite
Concomitant administration of Levipil and methotrexate has been reported to decrease methotrexate clearance
Isolated reports of decreased Levipil efficacy when concomitantly administered with oral osmotic laxative macrogol

Contraindications

Hypersensitivity to the active substance or other pyrrolidone derivatives or to any of the excipients

Side effects

Most common adverse reactions include somnolence, asthenia, infection, dizziness in adult patients
Fatigue, aggression, nasal congestion, decreased appetite, irritability in pediatric patients

Pregnancy lactation

Levetiracetam is not recommended during pregnancy and in women of childbearing potential not using contraception unless clinically necessary. Levetiracetam is excreted in human breast milk, therefore, breastfeeding is not recommended.

Precautions warnings

Administration to patients with renal impairment may require dose adjustment
Rare cases of decreased blood cell counts have been described in association with Levipil administration
Suicidal thoughts and behaviours have been reported in patients treated with anti-epileptic agents

Special populations

Adjustment of the dose is recommended in elderly patients with compromised renal function
No dose adjustment is needed in patients with mild to moderate hepatic impairment
50% reduction of the daily maintenance dose is recommended in patients with severe hepatic impairment

Overdose effects

Observations of somnolence, agitation, aggression, depressed level of consciousness, respiratory depression, and coma with Levipil overdoses
No specific antidote for Levipil, treatment will be symptomatic