Oxetol 300 mg (Tablet)

Indications

• Monotherapy in the treatment of partial seizures in adults
• Adjunctive therapy in the treatment of partial seizures in adults
• Monotherapy in the treatment of partial seizures in children aged 4-16 years
• Adjunctive therapy in the treatment of partial seizures in children aged 2–16 years

Pharmacology

• Mechanism of action involves blockade of voltage-sensitive sodium channels
• Resulting in stabilization of hyper excited neural membranes
• Inhibition of repetitive neuronal firing
• Diminishment of propagation of synaptic impulses

Dosage & Administration

• Recommended starting dose for adults is 600 mg/day
• Maximum recommended daily dose for adults is 2400 mg/day
• Recommended starting dose for pediatrics is 8 to 10 mg/kg/day
• Maximum maintenance dose in pediatrics should not exceed 60 mg/kg/day

Interaction

• Inhibits the enzyme CYP2C19
• Could interact with medicinal products metabolized by CYP2C19
• Potential interactions with phenobarbital and phenytoin
• May affect the effectiveness of hormonal contraceptives

Contraindications

• Contraindicated in patients with hypersensitivity to the active substance or any of the excipients

Side Effects

• Common adverse reactions include somnolence, headache, dizziness, nausea, and vomiting
• Clinically significant hyponatremia reported rarely
• Possible rash, pruritus, or urticaria
• Reports of anaphylaxis

Pregnancy & Lactation

• May cause serious birth defects when administered during pregnancy
• Avoid use during pregnancy and lactation

Precautions & Warnings

• Caution with alcohol consumption due to potential additive sedative effect
• Gradual withdrawal recommended to minimize potential for increased seizure frequency

Therapeutic Class

• Adjunct anti-epileptic drugs

Related Brands

• Oxetol 150 mg (Tablet) - sun-pharmaceutical-bangladesh-ltd