Trileptal 300 mg (Tablet)
Unit Price: ৳ 20.06 (5 x 10: ৳ 1,003.00)
Strip Price: ৳ 200.60
Medicine Details
| Category | Details |
|---|---|
| Generic | Oxcarbazepine |
| Company | Novartis bangladesh ltd |
| Also available as |
Indications
- Monotherapy in adults for partial seizures
- Adjunctive therapy in adults for partial seizures
- Monotherapy in children (4-16 years) for partial seizures
- Adjunctive therapy in children (2-16 years) for partial seizures
Pharmacology
Exerts activity through the metabolite derivative (MHD) of Oxcarbazepine by blocking voltage-sensitive sodium channels
Dosage & Administration
- Adults:
- Initiation: 600 mg/day given twice-a-day
- Adjunctive Therapy: Maximum increment of 600 mg/day at weekly intervals, recommended daily dose of 1200 mg/day
- Conversion to Monotherapy: Withdrawal concomitant over 3 to 6 weeks, reach maximum dose of Oxcarbazepine in 2 to 4 weeks with increments of 600 mg/day at weekly intervals to a recommended daily dose of 2400 mg/day
- Initiation of Monotherapy: Increments of 300 mg/day every third day to a dose of 1200 mg/day
- Special Consideration: Initiate at one half the usual starting dose and increase slowly for patients with creatinine clearance <30 mL/min
- Pediatrics:
- Initiation: 8 to 10 mg/kg/day given twice-a-day, starting dose of 16 to 20 mg/kg/day may be considered for patients aged 2 to <4 years and under 20 kg
- Adjunctive Patients (Aged 2-16 Years): Target maintenance dose should be achieved over 2 weeks
- Conversion to Monotherapy for Patients (Aged 4-16 Years): Maximum increment of 10 mg/kg/day at weekly intervals
- Initiation of Monotherapy for Patients (Aged 4-16 Years): Increments of 5 mg/kg/day every third day
Interaction
- Inhibition of CYP2C19 enzyme
- Potential interactions with medicinal products metabolized by CYP2C19
- Effect on hormonal contraceptives
- Impact on felodipine and verapamil bioavailability
Contraindications
Hypersensitivity to the active substance or excipients
Side Effects
- Somnolence
- Headache
- Dizziness
- Diplopia
- Nausea
- Vomiting
- Fatigue
- Hyponatremia
- Hypersensitivity reactions such as rash, pruritus, and urticaria
Pregnancy & Lactation
- Pregnancy: Potential serious birth defects and bleeding disorders reported
- Lactation: Excretion in breast milk, should not be used during breastfeeding
Precautions & Warnings
- Caution with alcohol consumption
- Gradual withdrawal to minimize increased seizure frequency
Therapeutic Class
Adjunct anti-epileptic drugs