Trileptal 60 mg/ml (Oral Suspension)
100 ml bottle: ৳ 1,072.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Oxcarbazepine |
| Company | Novartis bangladesh ltd |
| Also available as |
Indications
- Monotherapy in the treatment of partial seizures in adults
- Adjunctive therapy in the treatment of partial seizures in adults
- Monotherapy in the treatment of partial seizures in children aged 4-16 years
- Adjunctive therapy in the treatment of partial seizures in children aged 2-16 years
Pharmacology
- Primary activity exerted through the metabolite derivative (MHD) of Oxcarbazepine
- Mechanism of action based on blockade of voltage-sensitive sodium channels
- Stabilization of hyper excited neural membranes
- Inhibition of repetitive neuronal firing
- Diminishment of propagation of synaptic impulses
Dosage & Administration
- Recommended daily dose for adults is 1200 mg/day
- Maximum daily dose for adults is 2400 mg/day
- Dosage initiation with 600 mg/day for adults
- Dosage initiation with 8 to 10 mg/kg/day for pediatrics aged 2 and above
- Dosage initiation with 16 to 20 mg/kg/day for pediatrics aged 4 and below
- Dosage adjustment for patients with creatinine clearance <30 mL/min
- Conversion to monotherapy with gradual withdrawal of concomitant antiepileptic drugs
Interaction
- Inhibition of the enzyme CYP2C19 by Trileptal and its metabolite
- Potential interactions with medicinal products metabolized by CYP2C19
- Reduced effectiveness of hormonal contraceptives when co-administered with Trileptal
Contraindications
- Hypersensitivity to the active substance or any of the excipients
Side Effects
- Common adverse reactions: somnolence, headache, dizziness, diplopia, nausea, vomiting, fatigue
- Rare occurrence of clinically significant hyponatremia
- Reports of Class I (immediate) hypersensitivity reactions
Pregnancy & Lactation
- Potential for serious birth defects (e.g., cleft palate) when administered during pregnancy
- Transmission of Oxcarbazepine and its active metabolite (MHD) to the newborn
- Excretion of Oxcarbazepine and MHD in human breast milk
Precautions & Warnings
- Caution advised when combining alcohol with Oxazep therapy due to possible additive sedative effect
- Gradual withdrawal recommended to minimize potential for increased seizure frequency
Therapeutic Class
- Adjunct anti-epileptic drugs