Barbit 30 mg (Tablet)

Unit Price: ৳ 1.00 (10 x 10: ৳ 100.00)
Strip Price: ৳ 10.00

Medicine Details

Category Details
Generic Phenobarbital
Company Incepta pharmaceuticals ltd
Also available as
Barbit 60 mg tablet Barbit elixir 20 mg oral solution Barbit 200 mg injection

Indications

  • Sedatives
  • Hypnotics for short-term treatment of insomnia
  • Pre-anesthetics
  • Anticonvulsants for generalized tonic-clonic and cortical local seizures
  • Emergency control of acute convulsive episodes

Description

Barbit is a barbiturate, nonselective, central nervous system depressant primarily used as a sedative hypnotic and anticonvulsant in subhypnotic doses.

Pharmacology

Phenobarbital acts on GABAA receptors, increasing synaptic inhibition, elevating seizure threshold, and reducing the spread of seizure activity. It may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal.

Dosage & Administration

  • Pediatric Oral Dosage:
    • Preoperative: 1 mg to 3 mg/kg
    • Anticonvulsant: 1 mg to 6 mg/kg per day
  • Adult Oral Dosage:
    • Daytime sedative: 30 mg to 120 mg daily in 2 to 3 divided doses
    • Bedtime hypnotic: 100 mg to 320 mg
    • Anticonvulsant: 50 mg to 100 mg 2 to 3 times daily
  • Pediatric Injection Dosage:
    • 15 to 20 mg/kg IV over 10 to 15 min
    • Preoperative Sedation: 1 to 3 mg/kg IM/IV
    • Anticonvulsant: 4 to 6 mg/kg IM/IV per day, for 10 days. Alternatively, use 10 to 15 mg/kg IM/IV per day to reach therapeutic level more quickly. Maxium IV rate 60 mg/min
  • Adult Injection Dosage:
    • Insomnia: 100 to 320 mg IM/IV
    • Convulsions: 100 to 320 mg IV. Repeat if needed (maximum, 600 mg per day)
    • Status Epilepticus: 10 to 20 mg/kg IV. Repeat if needed.

Interaction

Concomitant use of alcohol or other CNS depressants may produce additive CNS depressant effects.

Contraindications

Phenobarbital is contraindicated in patients with known Phenobarbital sensitivity or a history of latent porphyria.

Side Effects

  • Somnolence
  • Agitation
  • Confusion
  • Hyperkinesia
  • CNS depression
  • Nightmares
  • Nervousness
  • Psychiatric disturbance
  • Hallucinations
  • Insomnia
  • Anxiety
  • Dizziness
  • Apnea
  • Bradycardia
  • Hypotension
  • Nausea
  • Vomiting
  • Constipation

Pregnancy & Lactation

Pregnancy Category D. Phenobarbital can cause fetal damage when administered to a pregnant woman. Caution should be taken when administered to a nursing woman since small amounts of Phenobarbital are excreted in the milk.

Precautions & Warnings

Tolerance and psychological/physical dependence may occur with continuing use. Administer with caution to patients who are mentally depressed, have suicidal tendencies, or a history of drug abuse. Use caution and initially reduce doses in patients with hepatic damage.

Overdose Effects

The toxic dose of barbiturates varies. Acute overdosage is manifested by CNS and respiratory depression. Treatment is mainly supportive and immediate hospitalization is necessary.

Therapeutic Class

  • Adjunct anti-epileptic drugs
  • Barbiturates

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

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