G-Phenobarbitone 200 mg/ml (Injection)
1 ml ampoule: ৳ 15.00 (1 x 5: ৳ 75.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Phenobarbital |
| Company | Gonoshasthaya pharma ltd |
| Also available as |
Indications
- Sedatives
- Hypnotics for short-term treatment of insomnia
- Pre-anesthetics
- Long-term anticonvulsants for treatment of generalized tonic-clonic and cortical local seizures
- Emergency control of certain acute convulsive episodes
Description
- Barbiturate
- Nonselective central nervous system depressant
- Primarily used as a sedative hypnotic
- Also used as an anticonvulsant in subhypnotic doses
Pharmacology
- Acts on GABA receptors
- Increases synaptic inhibition
- Elevates seizure threshold
- Reduces spread of seizure activity
- Inhibits calcium channels
- Decreases excitatory transmitter release
- Effect on polysynaptic midbrain reticular formation controlling CNS arousal
Dosage & Administration
- Pediatric and adult oral dosage
- Pediatric and adult injection dosage
- Specific doses for sedative, hypnotic, and anticonvulsant purposes
Interaction
- Concomitant use of alcohol or other CNS depressants producing additive effects
Contraindications
- Patients with known Phenobarbital sensitivity
- History of latent porphyria
Side Effects
- Somnolence
- Agitation
- Confusion
- Hyperkinesia
- Ataxia
- Nightmares
- Nervousness
- Psychiatric disturbance
- Hallucinations
- Insomnia
- Anxiety
- Dizziness
- Apnea
- Bradycardia
- Hypotension
- Nausea
- Vomiting
- Constipation
Pregnancy & Lactation
- Pregnancy Category D
- Potential fetal damage
- Risk to the fetus
- Excretion in breast milk
Precautions & Warnings
- Tolerance and dependence precautions
- Administration caution for mentally depressed patients
- Administration caution for patients with suicidal tendencies
- Initial reduced doses for patients with hepatic damage
Overdose Effects
- Toxic dose variation
- CNS and respiratory depression
- Supportive treatment for overdosage
- Immediate hospitalization
Therapeutic Class
- Adjunct anti-epileptic drugs
- Barbiturates
Storage Conditions
- Keep below 30°C temperature
- Keep away from light & moisture
- Keep out of the reach of children