Gabarol 25 mg (Capsule)

Indications

• Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
• Postherpetic neuralgia (PHN)
• Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
• Fibromyalgia
• Neuropathic pain associated with spinal cord injury

Pharmacology

• Structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
• Binds with high affinity to the alpha2-delta site in central nervous system tissues

Dosage

• Maximum recommended dose of 100 mg three times a day for DPN
• Recommended dose of 75 to 150 mg two times a day or 50 to 100 mg three times a day for PHN
• Recommended dose of 300 to 450 mg/day for fibromyalgia
• Recommended dose range of 150 to 600 mg/day for spinal cord injury
• Recommended dose of Pregabalin CR capsule is 165 mg once daily and increase to 330 mg once daily within 1 week
• Total daily dose for Pregabalin CR capsule based on Pregabalin tablet dose

Administration

• Taken in oral route
• Can be taken with or without food
• Pregabalin CR tablet should be administered after an evening meal
• Swallowed whole and should not be split, crushed, or chewed
• Gradually tapered when discontinuing

Interaction

• Unlikely to be involved in significant pharmacokinetic drug interactions
• No significant drug interaction with food and others

Contraindications

• Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components

Side Effects

• Common side effects in adults include dizziness, somnolence, dry mouth, edema, blurred vision, and weight gain
• Common side effects in pediatric patients for the treatment of partial onset seizures are increased weight and increased appetite

Pregnancy & Lactation

• No adequate and well-controlled studies in pregnant women
• Small amounts detected in the milk of lactating women
• Breastfeeding not recommended due to potential risk of tumorigenicity

Precautions & Warnings

• Angioedema may occur and require immediate discontinuation
• Discontinuation should be gradual
• Increased risk of suicidal thoughts or behavior
• Respiratory depression may occur when used with concomitant CNS depressants
• May cause dizziness and impair patient's ability to drive or operate machinery

Use in Special Populations

• Safety and effectiveness in pediatric patients not established for certain indications
• Not established in pediatric patients below the age of 1 month

Overdose Effects

• Signs and symptoms include reduced consciousness, depression/anxiety, and seizures
• No specific antidote

Therapeutic Class

• Adjunct anti-epileptic drugs
• Primary anti-epileptic drugs

Storage Conditions

• Keep in a cool & dry place (below 30°C)
• Protected from light & moisture
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C8H17NO2

Common Questions

• What is Gabarol 25 mg Capsule?
• How long do I need to use Gabarol 25 mg Capsule before I see improvement in my condition?
• At what frequency do I need to use Gabarol 25 mg Capsule?
• Should I use Gabarol 25 mg Capsule empty stomach, before food or after food?
• What are the instructions for the storage and disposal of Gabarol 25 mg Capsule?
• Does Gabarol 25 mg Capsule work in the same way for each disease?
• How long do I need to take Gabarol 25 mg Capsule?
• Is it necessary to continue taking Gabarol 25 mg Capsule even if I feel fine?
• Can I take Diazepam and Gabarol 25 mg Capsule together?
• Can the use of Gabarol 25 mg Capsule cause weight gain?
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Related Brands

• GABA-P 50 mg (Capsule) - renata-limited
• GABA-P 75 mg (Capsule) - renata-limited