Pregaba 75 mg (Capsule)
Unit Price: ৳ 19.00 (3 x 10: ৳ 570.00)
Strip Price: ৳ 190.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pregabalin |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
- Postherpetic neuralgia (PHN)
- Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
- Fibromyalgia
- Neuropathic pain associated with spinal cord injury
Pharmacology
- Structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
- Binds with high affinity to the alpha2-delta site in central nervous system tissues
Dosage
- Maximum recommended dose of 100 mg three times a day for patients with creatinine clearance of at least 60 ml/min
- Recommended dose of 75 to 150 mg two times a day for postherpetic neuralgia in adults
- Maximum recommended dose of 660 mg once daily for fibromyalgia in adults
- Recommended dose range of 150 to 600 mg/day for neuropathic pain associated with spinal cord injury in adults
- Conversion from Pregabalin capsules to Pregabalin CR capsule tablet
Administration
- Oral route of administration
- Should be swallowed whole and should not be split, crushed or chewed
- Administered after an evening meal
- Gradual tapering over a minimum of 1 week when discontinuing
Interaction
- Unlikely to be involved in significant pharmacokinetic drug interactions
Contraindications
- Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components
Side Effects
- Dizziness
- Somnolence
- Dry mouth
- Edema
- Blurred vision
- Weight gain
- Difficulty with concentration/attention
- Increased weight and increased appetite in pediatric patients
Pregnancy & Lactation
- No adequate and well-controlled studies with pregabalin in pregnant women
- Small amounts of pregabalin have been detected in the milk of lactating women
- Breastfeeding not recommended during treatment with pregabalin
Precautions & Warnings
- Angioedema
- Hypersensitivity reactions
- Increased risk of suicidal thoughts or behavior
- Respiratory depression
- Dizziness and somnolence affecting driving or operating machinery
- Increased seizure frequency or other adverse reactions if rapidly discontinued
- Peripheral edema
- Cautious coadministration with thiazolidinedione antidiabetic agents
Use in Special Populations
- Safety and effectiveness not established in pediatric patients for certain indications
- Safety and effectiveness not established for pediatric patients below the age of 1 month for adjunctive therapy for partial onset seizures
- Safety and effectiveness of Pregaba extended-release tablet not established in pediatric patients
Overdose Effects
- Reduced consciousness
- Depression/anxiety
- Confusional state
- Agitation and restlessness
- Seizures
- Heart block
Therapeutic Class
- Adjunct anti-epileptic drugs
- Primary anti-epileptic drugs
Storage Conditions
- Keep in a cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C8H17NO2
- Chemical Structure image available
Common Questions
- Treatment for neurotic pain, shingles, seizures, and fibromyalgia
- Duration of use
- Frequency of use
- Instructions for storage and disposal
- Differences in effects for different diseases
- Duration of use
- Necessity to continue usage even if feeling fine
- Potential drug interactions with Diazepam
- Potential for weight gain
- Quick Tips for usage
Route of Administration
Oral route
Maximum Recommended Dose
100 mg three times a day
Dosage for Postherpetic Neuralgia in Adults
75 to 150 mg two times a day or 50 to 100 mg three times a day
Dosage for Fibromyalgia in Adults
300 to 450 mg/day
Dosage Range for Neuropathic Pain associated with Spinal Cord Injury in Adults
150 to 600 mg/day
Storage Temperature
Below 30°C
Hypersensitivity Reactions
- Angioedema
- Hives
- Dyspnea
- Wheezing
Respiratory Depression Monitoring
Patients need to be monitored and dosage adjusted as appropriate
Peripheral Edema Caution
Caution should be exercised when coadministering Pregaba and thiazolidinedione antidiabetic agents