Pregadel 50 mg (Capsule)

Unit Price: ৳ 10.00 (3 x 8: ৳ 240.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Pregabalin
Company Delta pharma ltd
Also available as
Pregadel 75 mg capsule Lyca cr 825 mg tablet Lyca cr 165 mg tablet

Title

  • Pregadel 50 mg Capsule

Categories

  • Medicine
  • Anticonvulsant
  • Neuropathic Pain Relief
  • Seizure Control
  • Fibromyalgia Management

Description

  • Pregadel 50 mg Capsule is an anticonvulsant and is considered to be the first-line of treatment for neuropathic pain, shingles, seizures, and fibromyalgia.

Dosage and administration

  • Maximum recommended dose of Pregabalin is 100 mg three times a day for adults with diabetic peripheral neuropathy
  • Recommended dose of Pregabalin is 75 to 150 mg two times a day for postherpetic neuralgia in adults
  • Recommended dose of Pregabalin is 300 to 450 mg/day for fibromyalgia management in adults
  • Recommended dose range of Pregabalin is 150 to 600 mg/day for neuropathic pain associated with spinal cord injury in adults
  • Pregabalin tablet to Pregabalin CR capsule dosage conversion guide provided
  • Route of administration: Oral, with or without food
  • Pregabalin CR tablet should be administered after an evening meal
  • Dosage adjustments and tapering guidelines for gradual discontinuation

Pharmacology

  • Structural derivative of inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
  • Binds with high affinity to the alpha2-delta site in central nervous system tissues
  • Anti-nociceptive and antiseizure effects

Contraindications

  • Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components

Side effects

  • Most common side effects in adults: dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, thinking abnormal
  • Most common side effects in pediatric patients: increased weight, increased appetite

Pregnancy and lactation

  • No adequate and well-controlled studies with pregabalin in pregnant women
  • Small amounts of pregabalin detected in the milk of lactating women
  • Breastfeeding not recommended due to potential risk of tumorigenicity

Precautions and warnings

  • Potential occurrence of angioedema requiring immediate discontinuation
  • Discontinuation if hypersensitivity reactions occur
  • Increased risk of suicidal thoughts or behavior
  • Monitoring and dosage adjustment for respiratory depression
  • Advice against driving or operating machinery
  • Caution with coadministration of Pregadel and thiazolidinedione antidiabetic agents

Use in special populations

  • Safety and effectiveness in pediatric patients not established for various conditions

Overdose effects

  • Signs and symptoms include reduced consciousness, depression/anxiety, seizures, heart block

Drug interactions

  • Unlikely to be involved in significant pharmacokinetic drug interactions
  • No significant interactions with food and others

Storage conditions

  • Keep in a cool & dry place, protected from light & moisture, out of the reach of children

Chemical structure

  • Molecular Formula: C8H17NO2

Commonly asked questions

  • Pregadel 50 mg Capsule should be taken as per the dose and duration prescribed by a doctor
  • May cause sleepiness, blurred vision, and mood changes; precautions advised

Indications

  • Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
  • Postherpetic neuralgia (PHN)
  • Adjunctive therapy for partial-onset seizures
  • Fibromyalgia management
  • Neuropathic pain associated with spinal cord injury

Interaction

  • Pregadel is unlikely to be involved in significant pharmacokinetic drug interactions.
  • No significant drug interaction with food and others

Therapeutic class

  • Adjunct anti-epileptic drugs
  • Primary anti-epileptic drugs

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