Pregalex 75 mg (Capsule)
Unit Price: ৳ 16.04 (3 x 10: ৳ 481.20)
Strip Price: ৳ 160.40
Medicine Details
| Category | Details |
|---|---|
| Generic | Pregabalin |
| Company | Sharif pharmaceuticals ltd |
| Also available as |
Title
- Pregalex 75 mg Capsule
Categories
- Medicine
- Pharmaceuticals
Description
- Neuropathic pain relief
- Treatment of partial-onset seizures
- Management of fibromyalgia
- Adjunct therapy for postherpetic neuralgia
- Treatment of neuropathic pain associated with spinal cord injury
- Anticonvulsant
- Structural derivative of GABA
- Inhibitory neurotransmitter
Dosage
- 100 mg three times a day for DPN (300 mg/day)
- 165 mg once daily for Pregabalin CR
- 75 to 150 mg two times a day or 50 to 100 mg three times a day for PHN (150 to 300 mg/day)
- 300 to 450 mg/day for fibromyalgia
- 150 to 600 mg/day for spinal cord injury
- Dose adjustment based on individual patient response and tolerability
Administration
- Oral route
- Can be taken with or without food
- Pregabalin CR tablet should be administered after an evening meal
- Swallowed whole, not split, crushed, or chewed
- Gradual tapering when discontinuing
Indications
- Neuropathic pain associated with DPN
- Postherpetic neuralgia
- Adjunctive therapy for partial-onset seizures
- Fibromyalgia
- Neuropathic pain associated with spinal cord injury
Pharmacology
- Binds with high affinity to the alpha2-delta site in central nervous system tissues
- Anti-nociceptive and antiseizure effects
- Mechanism of action not fully elucidated
Mode of Action
- Binds to alpha2-delta subunit
- Involvement in anti-nociceptive and antiseizure effects
Drug Interaction
- Unlikely to be involved in significant pharmacokinetic drug interactions
- No significant interaction with food
Contraindications
- Known hypersensitivity to Pregabalin or any of its components
Side Effects
- Dizziness
- Somnolence
- Dry mouth
- Edema
- Blurred vision
- Weight gain
- Difficulty with concentration/attention
- Increased weight and appetite in pediatric patients
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Potential risk to fetus
- Small amounts detected in the milk of lactating women
- Breastfeeding not recommended
Precautions & Warnings
- Angioedema
- Hypersensitivity reactions
- Increased risk of suicidal thoughts or behavior
- Respiratory depression with concomitant CNS depressants
- Impairment of ability to drive or operate machinery
- Caution with coadministering with thiazolidinedione antidiabetic agents
Use in Special Populations
- Safety and effectiveness not established in pediatric patients
- Not established for patients below 1 month of age
Overdose Effects
- Reduced consciousness
- Depression/anxiety
- Agitation and restlessness
- Seizures and heart block reported
- No specific antidote
- General supportive care indicated
Therapeutic Class
- Adjunct anti-epileptic drugs
- Primary anti-epileptic drugs
Storage Conditions
- Keep in a cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C8H17NO2
Common Questions
- Potential first-line treatment for neurotic pain, shingles, seizures, and fibromyalgia
- Duration of usage depends on health condition and should be prescribed by a doctor
- Dosage should be adhered to as prescribed by the doctor
- Should be taken after food in prescribed dosage
- Storage should be in a cool dry place and in its original packaging
- Works differently for different diseases
- Duration of usage depends on the specific health condition
- It is necessary to continue usage even if feeling fine
- Can be used in conjunction with Diazepam
- May cause weight gain, consult a dietician if concerned