Convules 200 mg/5 ml (Syrup)

Indications

• Treatment of all types of epilepsy
• Treatment of bipolar disorder
• Prophylaxis of migraine
• Prophylaxis of febrile convulsion
• Prophylaxis of post-traumatic epilepsy

Composition

• Sodium Valproate tablet 200 mg
• Sodium Valproate syrup 200 mg/5ml
• Sodium Valproate controlled release 200 tablet
• Sodium Valproate controlled release 300 tablet
• Sodium Valproate controlled release 500 tablet
• Sodium Valproate injection 500 mg/5ml

Pharmacology

• Endowed with anti-epileptic activity
• Mechanism related to increased brain levels of gamma-aminobutyric acid (GABA)

Dosage & Administration

• Oral administration
• Initial dosage for epilepsy: Adults - 600 mg daily, Children (over 20 kg) - 400 mg daily, Children (up to 20 kg) - 20 mg/kg daily
• Maintenance dosage for epilepsy: 1-2 g daily for adults, 20-30 mg/kg daily for children
• Dosage for bipolar disorder: Initially 600 mg daily, Maintenance dosage 1000-2000 mg daily
• Dosage for prophylaxis of migraine: 400-600 mg daily, may require 1000-1500 mg daily
• Injection administration: IV injection over 3-5 minutes, continuous or repeated infusion

Interaction

• Non-specific inhibitor of drug metabolism
• Significant interaction with Phenobarbital, Phenytoin, Warfarin, Aspirin

Contraindications

• Known hypersensitivity to the drug
• Liver dysfunction
• Restricted use during pregnancy and in women of childbearing potential

Side Effects

• Anorexia, nausea, vomiting
• CNS effects: sedation, ataxia, tremor
• Minimized side effects with enteric coated tablets
• Rash, alopecia, stimulation of appetite
• Elevation of liver enzymes in plasma
• Hepatic injury, acute pancreatitis, hyperammonemia
• Fulminate hepatitis (rare)

Pregnancy & Lactation

• Crosses the placenta
• Associated with neural tube defects in first trimester exposure
• Excreted in breast milk, probably causes no risk to the child

Precautions & Warnings

• Monitoring of liver functions
• Ensuring no undue potential for bleeding
• Care in renal impairment, pregnancy, breast-feeding, systemic lupus erythematosus
• False interpretation of urine ketone test due to metabolite
• Avoid sudden withdrawal of therapy

Therapeutic Class

• Primary anti-epileptic drugs

Storage Conditions

• Do not store above 30°C
• Keep away from light
• Keep out of the reach of children

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