Convules 200 mg/5 ml (Syrup)

100 ml bottle: ৳ 85.00

Medicine Details

Category Details
Generic Sodium valproate
Company Opsonin pharma ltd
Also available as
Convules cr 200 mg tablet Convules cr 300 mg tablet Convules cr 500 mg tablet

Indications

  • Treatment of all types of epilepsy
  • Treatment of bipolar disorder
  • Prophylaxis of migraine
  • Prophylaxis of febrile convulsion
  • Prophylaxis of post-traumatic epilepsy

Composition

  • Sodium Valproate tablet 200 mg
  • Sodium Valproate syrup 200 mg/5ml
  • Sodium Valproate controlled release 200 tablet
  • Sodium Valproate controlled release 300 tablet
  • Sodium Valproate controlled release 500 tablet
  • Sodium Valproate injection 500 mg/5ml

Pharmacology

  • Endowed with anti-epileptic activity
  • Mechanism related to increased brain levels of gamma-aminobutyric acid (GABA)

Dosage & Administration

  • Oral administration
  • Initial dosage for epilepsy: Adults - 600 mg daily, Children (over 20 kg) - 400 mg daily, Children (up to 20 kg) - 20 mg/kg daily
  • Maintenance dosage for epilepsy: 1-2 g daily for adults, 20-30 mg/kg daily for children
  • Dosage for bipolar disorder: Initially 600 mg daily, Maintenance dosage 1000-2000 mg daily
  • Dosage for prophylaxis of migraine: 400-600 mg daily, may require 1000-1500 mg daily
  • Injection administration: IV injection over 3-5 minutes, continuous or repeated infusion

Interaction

  • Non-specific inhibitor of drug metabolism
  • Significant interaction with Phenobarbital, Phenytoin, Warfarin, Aspirin

Contraindications

  • Known hypersensitivity to the drug
  • Liver dysfunction
  • Restricted use during pregnancy and in women of childbearing potential

Side Effects

  • Anorexia, nausea, vomiting
  • CNS effects: sedation, ataxia, tremor
  • Minimized side effects with enteric coated tablets
  • Rash, alopecia, stimulation of appetite
  • Elevation of liver enzymes in plasma
  • Hepatic injury, acute pancreatitis, hyperammonemia
  • Fulminate hepatitis (rare)

Pregnancy & Lactation

  • Crosses the placenta
  • Associated with neural tube defects in first trimester exposure
  • Excreted in breast milk, probably causes no risk to the child

Precautions & Warnings

  • Monitoring of liver functions
  • Ensuring no undue potential for bleeding
  • Care in renal impairment, pregnancy, breast-feeding, systemic lupus erythematosus
  • False interpretation of urine ketone test due to metabolite
  • Avoid sudden withdrawal of therapy

Therapeutic Class

  • Primary anti-epileptic drugs

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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