Encorate 200 mg (Tablet)

Indications

• Treatment of epilepsy
• Prophylaxis of febrile convulsion
• Prophylaxis of post-traumatic epilepsy
• Treatment of bipolar disorder
• Prophylaxis of migraine

Dosage & Administration

• Oral administration
• Twice daily dosing
• Divided doses
• Intravenous injection
• Slow intravenous injection

Composition

• Sodium Valproate tablet 200 mg
• Sodium Valproate syrup 200 mg/5ml
• Sodium Valproate controlled release 200 tablet
• Sodium Valproate controlled release 300 tablet
• Sodium Valproate controlled release 500 tablet
• Sodium Valproate injection 500 mg/5ml

Pharmacology

• Anti-epileptic activity
• Mechanism related to increasing brain levels of GABA

Interaction

• Inhibition of drug metabolism
• Interacts with Phenobarbital
• Interacts with Phenytoin
• Interacts with Warfarin
• Interacts with Aspirin

Contraindications

• Known hypersensitivity
• Liver dysfunction
• Pregnancy
• Women of childbearing potential

Side Effects

• Anorexia
• Nausea
• Vomiting
• Sedation
• Ataxia
• Tremor
• Rash
• Alopecia
• Elevation of liver enzymes
• Hepatic injury
• Acute pancreatitis
• Hyperammonemia

Pregnancy & Lactation

• Crosses placenta
• Associated with neural tube defects
• Excreted in breast milk

Precautions & Warnings

• Liver function monitoring
• No undue potential for bleeding
• Care in renal impairment
• Care in pregnancy
• Care in breast-feeding
• Care in lupus erythematosus
• Sudden withdrawal avoidance

Therapeutic Class

• Primary anti-epileptic drugs

Storage Conditions

• Store below 30°C
• Keep away from light
• Keep out of the reach of children

Related Brands

• Valex 500 mg/5 ml (IV Injection) - incepta-pharmaceuticals-ltd
• Sodival CR 500 mg (Tablet (Controlled Release)) - aci-limited
• Valporin CR 200 mg (Tablet (Controlled Release)) - renata-limited
• Valporin CR 300 mg (Tablet (Controlled Release)) - renata-limited
• Valporin CR 500 mg (Tablet (Controlled Release)) - renata-limited