Valex CR 200 mg (Tablet (Controlled Release))

Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Sodium valproate
Company Incepta pharmaceuticals ltd
Also available as
Valex 200 mg tablet Valex 200 mg syrup Valex cr 300 mg tablet Valex cr 500 mg tablet Valex 500 mg injection

Indications

  • Treatment of all types of epilepsy
  • Prophylaxis of febrile convulsion
  • Treatment of bipolar disorder
  • Prophylaxis of migraine

Composition

  • Enteric-coated tablet containing Sodium Valproate BP 200 mg
  • Syrup containing Sodium Valproate BP 200 mg
  • Controlled release tablet containing Sodium Valproate 200 mg as Sodium Valproate BP 133.2 mg & Valproic acid BP 58 mg
  • Controlled release tablet containing Sodium Valproate 300 mg as Sodium Valproate BP 199.8 mg & Valproic acid BP 87 mg
  • Controlled release tablet containing Sodium Valproate 500 mg as Sodium Valproate BP 333 mg & Valproic acid BP 145 mg
  • Injectable solution containing Sodium Valproate BP eqv. to Valproic Acid 500 mg

Pharmacology

  • Anti-epileptic activity against a variety of seizures
  • Increase brain levels of gamma-aminobutyric acid (GABA)

Dosage & Administration

  • Oral administration
  • Initial dose for adults: 600 mg daily, increased by 200 mg/day at 3-day intervals
  • Usual maintenance dose for adults: 1-2 g daily
  • Initial dose for children (over 20 kg): 400 mg daily
  • Maximum dose for children (over 20 kg): 35 mg/kg daily
  • Initial dose for children (up to 20 kg): 20 mg/kg daily
  • Febrile convulsion dosage: 20-30 mg/kg/day in 3 divided doses
  • Bipolar disorder initial dosage: 600 mg daily, maintenance dosage: 1000-2000 mg daily
  • Prophylaxis of migraine dosage: 400-600 mg daily, some may require 1000-1500 mg daily
  • Injection administration for adults: usually 400-800 mg, followed by continuous or repeated infusion up to a maximum of 2500 mg/day
  • Injection administration for children: Initial 20-30 mg/kg/day, maximum 40 mg/kg/day

Interaction

  • Non-specific inhibitor of drug metabolism
  • Significant interaction with Phenobarbital, Phenytoin, Warfarin, Aspirin

Contraindications

  • Known hypersensitivity to the drug
  • Liver dysfunction
  • Restriction during pregnancy and in women of childbearing potential

Side Effects

  • Anorexia
  • Nausea
  • Vomiting
  • CNS effects: sedation, ataxia, tremor
  • Rash
  • Alopecia
  • Stimulation of appetite
  • Elevation of liver enzymes in plasma
  • Fulminate hepatitis (rare)
  • Hepatic injury in children below 2 years with other medical conditions
  • Acute pancreatitis
  • Hyperammonemia

Pregnancy & Lactation

  • Crosses the placenta
  • Associated with neural tube defects in newborn
  • Excreted in breast milk

Precautions & Warnings

  • Monitoring of liver functions before therapy and during first 6 months
  • No undue potential for bleeding before starting and before major surgery
  • Care should be taken in renal impairment, pregnancy, breast-feeding, and systemic lupus erythematosus
  • Partially eliminated in the urine as a ketone metabolite, leading to false interpretation of the urine ketone test
  • Sudden withdrawal of therapy should be avoided

Therapeutic Class

  • Primary anti-epileptic drugs

Storage Conditions

  • Do not store above 30°C
  • Keep away from light and out of the reach of children

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