Valex CR 300 mg (Tablet (Controlled Release))

Unit Price: ৳ 10.00 (5 x 10: ৳ 500.00)
Strip Price: ৳ 100.00

Medicine Details

Title

  • Valex CR Vaiproate

Categories

  • Medicine
  • Healthcare
  • Pharmaceuticals

Description

  • An oral medication for the treatment of epilepsy, bipolar disorder, and prophylaxis of migraine
  • Available in various forms: tablet, syrup, controlled release tablet, and injection
  • Contains Sodium Valproate as the active ingredient

Indications

  • Treatment of various types of epilepsy including partial, absence, generalized tonic-clonic, myoclonic, atonic, and mixed seizures
  • Prophylaxis of febrile convulsion and post-traumatic epilepsy
  • Treatment of bipolar disorder and prophylaxis of migraine

Composition

  • Enteric-coated tablets containing Sodium Valproate BP 200 mg
  • Syrup containing Sodium Valproate BP 200 mg per 5 ml
  • Controlled release tablets in 200 mg, 300 mg, and 500 mg strengths
  • Injectable solution containing Sodium Valproate BP equivalent to Valproic Acid 500 mg per 5 ml

Mode of Action

  • Endowed with anti-epileptic activity against a variety of seizures
  • Suggested mechanism of action related to increased brain levels of gamma-aminobutyric acid (GABA)

Dosage & Administration

  • Oral administration in divided doses for epilepsy, bipolar disorder, and prophylaxis of migraine
  • Initial adult dosage of 600 mg daily, increasing to a maximum of 2.5 g daily in divided doses for epilepsy
  • Intravenous injection for adults and children

Interaction

  • Acts as a non-specific inhibitor of drug metabolism
  • Significant interaction with drugs such as Phenobarbital, Phenytoin, Warfarin, and Aspirin

Contraindications

  • Contraindicated in patients with known hypersensitivity to the drug and liver dysfunction
  • Restricted use during pregnancy and in women of childbearing potential

Side Effects

  • Common side effects include anorexia, nausea, and vomiting
  • Effects on the CNS include sedation, ataxia, and tremor
  • Minimized side effects with the use of enteric-coated tablets

Pregnancy & Lactation

  • Crosses the placenta and associated with neural tube defects in newborns
  • Excreted in breast milk but likely causes no risk to the child

Precautions & Warnings

  • Monitor liver functions before and during therapy
  • Ensure no potential for bleeding before starting and before major surgery
  • Take caution in renal impairment, pregnancy, breast-feeding, and systemic lupus erythematosus
  • Avoid sudden withdrawal of therapy

Therapeutic Class

  • Primary anti-epileptic drugs

Storage Conditions

  • Do not store above 30°C
  • Keep away from light and out of the reach of children

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