Topmate 25 mg (Tablet)

Unit Price: ৳ 4.00 (5 x 10: ৳ 200.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Topiramate
Company Renata limited
Also available as
Topmate 50 mg tablet

Title

Topmate Tablets

Categories

  • Medicine
  • Antiepileptic
  • Migraine Prophylaxis

Description

Topmate tablets are indicated for monotherapy and adjunctive therapy for epilepsy in adults and children aged 6 years and above with generalised tonic-clonic seizures or partial seizures. It is also indicated for the prophylaxis of migraine headache in adults with frequent attacks. Topmate exerts pharmacological actions on seizures and migraines by stimulating GABA-A receptor activity and reducing glutamate activity.

Color Options

  • White

Dimensions

Various tablet sizes available

Functions

  • Seizure prevention
  • Migraine prophylaxis

Materials

  • Topiramate

Technical Specifications

  • Stimulates GABA-A receptor activity
  • Reduces glutamate activity
  • Inhibits voltage-dependent sodium channels

Dosage & Administration

  • Epilepsy Monotherapy:
    • Adults and children over 16 years: 25-400 mg/day
    • Children aged 6-16 years: 3-16 mg/kg/day
  • Epilepsy Adjunctive Therapy:
    • Adults and children over 16 years: 200-800 mg/day
    • Children aged 2-16 years: 5-9 mg/kg/day
  • Migraine:
    • Adults and children over 16 years: 50-100 mg/day

Interactions

  • Phenytoin
  • Carbamazepine
  • Valproic add
  • Phenobarbitai
  • Primidone
  • Alcohol
  • Oral Contraceptives
  • Lithium
  • Hydrochlorothiazide
  • Metformin
  • Pioglitazone
  • Glibenclamide
  • Benzodiazepines
  • Valproic Acid

Contraindications

  • Hypersensitivity to any component

Side Effects

  • Nausea
  • Abdominal pain
  • Dyspepsia
  • Dry mouth
  • Taste disturbance
  • Weight loss
  • Paraesthesia
  • Dizziness
  • Speech disorder
  • Insomnia
  • Anxiety
  • Depression
  • Visual disturbance
  • Suicidal ideation
  • Metabolic acidosis
  • Alopecia
  • Leucopenia
  • Thrombocytopenia
  • Serious skin reaction

Pregnancy & Lactation

Not recommended during pregnancy or breastfeeding

Precautions & Warnings

  • Gradual withdrawal in patients with or without history of seizures
  • Potential for central nervous system-related adverse events
  • Sedative effects
  • Visual disturbances/blurred vision

Overdose Effects

Severe metabolic acidosis. Treatment is supportive. Haemodialysis may be effective.

Therapeutic Class

Adjunct antiepileptic drugs

Storage Conditions

Keep below 30°C, away from light & moisture, out of reach of children

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