Topirva 50 mg (Tablet)
Unit Price: ৳ 10.00 (5 x 10: ৳ 500.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Topiramate |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Monotherapy for adults and children with newly diagnosed epilepsy
- Adjunctive therapy for inadequately controlled seizures
- Prophylaxis of migraine headache
Pharmacology
- Actions on voltage-dependent sodium channels
- Stimulation of GABA-A receptor activity
- Reduction of glutamate activity
- Inhibition of carbonic anhydrase isozymes
Dosage & Administration
- Titration for adults and children over 16 years
- Initial target dose for topiramate monotherapy
- Recommended total daily dose for adjunctive therapy
- Titration for children aged 6-16 years
- Titration for adults and children over 16 years for migraine prophylaxis
Interaction
- Effect on steady-state plasma concentrations of antiepileptic drugs
- CNS depressants caution
- Interaction with oral contraceptives
- Impact on lithium pharmacokinetics
- Influence on hydrochlorothiazide pharmacokinetics
- Effect on metformin pharmacokinetics
- Routine monitoring when co-administered with pioglitazone or glibenclamide
- Increase in the risk of nephrolithiasis
Contraindications
- Hypersensitivity to any component of this product
Side Effects
- Nausea
- Abdominal pain
- Dyspepsia
- Dry mouth
- Taste disturbance
- Weight loss
- Paraesthesia
- Hypoaesthesia
- Headache
- Fatigue
- Dizziness
- Speech disorder
- Insomnia
- Visual disturbance
- Suicidal ideation
- Metabolic acidosis
- Alopecia
Pregnancy & Lactation
- Not to be used during pregnancy unless potential benefit outweighs potential risk
- Not to be used during breastfeeding
Precautions & Warnings
- Gradual withdrawal to minimize potential for seizures
- Potential for sedative effects and drowsiness
- Reports of visual disturbances/blurred vision
- Advice against driving or operating machinery if affected
Overdose Effects
- Severe metabolic acidosis
- Immediate stomach emptying by lavage or emesis in acute overdose
- Activated charcoal adsorption
- Supportive treatment
- Effective removal via haemodialysis
- Hydration
Therapeutic Class
- Adjunct anti-epileptic drugs
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children