Cinemet CR 200 mg+50 mg (Tablet (Controlled Release))

Indications

• Idiopathic Parkinson's disease
• Reduce off-period in patients
• Motor fluctuations

Description

• Levodopa metabolic precursor of dopamine
• Carbidopa is a dopa decarboxylase (DDC) inhibitor

Dosage

• Substitution guideline with conventional levodopa/decarboxylase inhibitor combinations
• Dosing interval adjustment
• Titration guidance
• Maintenance and clinical evaluations
• Addition of other antiparkinson medication

Administration

• Dosage adjustment for different patient groups
• Titration for therapeutic response
• Maintenance and clinical evaluations
• Addition of other antiparkinson medication
• Therapeutic response observation during therapy interruption

Interaction

• Caution with specific drug combinations
• Effects of antihypertensive agents
• Interactions with antidepressants
• Impact of anticholinergics and iron
• Effects and observations with other drugs

Contraindications

• Contraindicated drugs and conditions
• Hypersensitivity and narrow-angle glaucoma
• Potential impact on malignant melanoma

Side Effects

• Most frequent side-effect - dyskinesia
• Incidence comparison with Levodopa-Carbidopa tablet
• Array of other reported side-effects

Pregnancy & Lactation

• Insufficient data for use in pregnancy
• Unknown excretion in human milk
• Recommendations for pregnant and nursing women

Precautions & Warnings

• Discontinuation and dyskinesias risk
• Recommended and prohibited uses
• Observations for specific patient groups
• Caution for cardiovascular and pulmonary diseases
• Advisories for driving and operating machines
• Control disorders monitoring
• Advisory for pediatric use

Use in Special Populations

• Not recommended for patients below the age of 18

Therapeutic Class

• Antiparkinson drugs

Storage Conditions

• Store in a cool and dry place
• Protection from light

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