Cyclid 5 mg (Tablet)

Indications

• adjunctive treatment of all forms of parkinsonian syndrome
• symptomatic treatment of idiopathic, postencephalitic and arteriosclerotic parkinsonian
• control of troublesome extrapyramidal symptoms
• treatment of pseudoparkinsonian, acute dystonic reactions and akathisia induced by neuroleptic drugs

Pharmacology

• antimuscarinic antiparkinsonian agent
• synthetic tertiary amine
• correction of relative cholinergic excess
• rapid absorption from the G.I. tract
• onset of action within 5 to 20 minutes
• duration of effect up to 4 hours

Dosage & Administration

• Tablet administered orally, preferably after meals
• initial dosage for parkinsonism: 2.5 mg 3 times a day, with a maximum total daily dose of 20 to 30 mg
• initial dosage for drug induced extrapyramidal symptoms: 2.5 mg 3 times a day, with incremental increases as needed
• IM or IV injection: 5-10 mg, repeated if necessary; maximum 20 mg daily

Interaction

• increased anticholinergic activity with certain agents
• reduced absorption of ketoconazole when administered concomitantly

Contraindications

• caution in children and geriatric patients
• caution in patients with diarrhoea, cardiovascular disease, glaucoma, urinary retention, hepatic or renal impairment
• unestablished safety during pregnancy and lactation
• no data available on drug excretion in breast milk

Side Effects

• dryness of the mouth at usual dosage levels
• mydriasis and blurred vision occasionally
• adverse G.I. effects including nausea, vomiting, epigastric distress, constipation
• occasional allergic reactions or muscular weakness
• possible vertigo, confusion, and hallucination at high doses
• adverse effects usually minimized by dosage adjustment and administration after meals

Pregnancy & Lactation

• weighing potential benefits against possible hazards
• safe use requires careful consideration

Precautions & Warnings

• consideration for hepatic & renal impairment, children, elderly, pregnancy, and lactation
• risk of psychotic episode precipitation in patients with mental disorders
• avoid abrupt withdrawal to prevent rebound Parkinsonism symptoms

Use in Special Populations

• safety and efficacy not established in the pediatric age group
• requires careful consideration of potential benefits and hazards

Therapeutic Class

Antiparkinson drugs

Storage Conditions

protect from light and moisture, store below 25°C, keep out of the reach of children

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