Kdrin 10 mg/2 ml (IM/IV Injection)
2 ml ampoule: ৳ 30.11 (1 x 5: ৳ 150.55)
Medicine Details
| Category | Details |
|---|---|
| Generic | Procyclidine hydrochloride |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Adjunctive treatment of parkinsonian syndrome
- Symptomatic treatment of idiopathic parkinsonian
- Symptomatic treatment of postencephalitic parkinsonian
- Symptomatic treatment of arteriosclerotic parkinsonian
- Control of extrapyramidal symptoms
- Treatment of pseudoparkinsonian symptoms
- Treatment of acute dystonic reactions
- Treatment of akathisia induced by neuroleptic drugs
Pharmacology
- Antimuscarinic antiparkinsonian agent
- Low toxicity
- Synthetic tertiary amine
- Corrects relative cholinergic excess
- Absorbed from G.I. tract
- Rapid disappearance from tissues
- Onset of action within 5-20 minutes
- Duration of effect up to 4 hours
Dosage & Administration
- Oral administration
- Preferred administration after meals
- Initial dose for parkinsonism: 2.5mg 3 times a day
- Dose adjustment for parkinsonism: up to 30mg daily
- Initial dose for drug induced extrapyramidal symptom: 2.5mg 3 times a day
- Dose adjustment for extrapyramidal symptom: as needed and tolerated
- IM or IV injection: 5-10mg, repeated if necessary; max 20mg daily
Interaction
- Increased anticholinergic activity with certain agents
- Reduced absorption of ketoconazole
Contraindications
- Use with caution in children and geriatric patients
- Caution in patients with diarrhea
- Caution in patients with cardiovascular disease
- Caution in patients with glaucoma
- Caution in patients with urinary retention
- Caution in patients with hepatic impairment
- Caution in patients with renal impairment
- Safety during pregnancy not established
- Safety during lactation not established
- No data on excretion in breast milk
Side Effects
- Dryness of the mouth
- Mydriasis
- Blurred vision
- G.I. effects (nausea, vomiting, constipation)
- Allergic reactions (e.g. rash)
- Muscular weakness
- Vertigo
- Confusion
- Hallucination
- Adverse effects minimized by dosage adjustment
Pregnancy & Lactation
- Benefit-risk assessment required for use during pregnancy
- Benefit-risk assessment required for use during lactation
Precautions & Warnings
- Precaution in hepatic impairment
- Precaution in renal impairment
- Precaution in children
- Precaution in elderly
- Precaution in pregnancy
- Precaution in lactation
- Potential precipitation of a psychotic episode in patients with mental disorders
- Avoid abrupt withdrawal to prevent rebound Parkinsonism symptoms
Use in Special Populations
- Safety and efficacy not established in pediatric age group
- Benefit-risk assessment required for use in children
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Protect from light and moisture
- Store below 25°C
- Keep out of reach of children