Hexinor 5 mg (Tablet)
Unit Price: ৳ 12.00 (6 x 10: ৳ 720.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Product Title
- Hexinor
Product Category
- Medicine
- Antiparkinson drugs
Product Description
- Adjunct in the treatment of all forms of parkinsonism
- Control of extrapyramidal disorders caused by central nervous system drugs
Pharmacological Class
- Muscarinic acetylcholine receptor antagonist
Indications
- Adjunct in the treatment of parkinsonism
- Useful as adjuvant therapy with levodopa
- Control of extrapyramidal disorders caused by CNS drugs
Mode of Action
- Direct inhibitory effect on the parasympathetic nervous system
- Relaxing effect on smooth musculature
- Higher affinity for central muscarinic receptors
Dosage Administration
- Individualized dosage
- Low initial dose, gradually increased
- Postencephalitic patients may prefer taking it after meals
- Abrupt withdrawal should be avoided
- Initial therapy for parkinsonism: 1 mg administered on the first day, increased by 2 mg increments
- Total daily dose range for idiopathic parkinsonism: 6 to 15 mg
- Total daily dosage for drug-induced parkinsonism: 5 to 15 mg
- Concomitant use with levodopa may require reduction in dose
- High doses best tolerated when divided into 3 or 4 parts
Interactions
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with alcohol or other CNS depressants
- Intensified anticholinergic effects with monoamine oxidase inhibitors and tricyclic antidepressants
- Risk of tardive dyskinesia with neuroleptics
- Possible need for reduction in levodopa or dosage of other parasympathetic inhibitors
Contraindications
- Hypersensitivity to trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Dilatation of the colon
- Paralytic ileus
- Psychiatric manifestations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy or retention
- Tachycardia
- Dilation of the pupil
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
- Exacerbation of parkinsonism with abrupt withdrawal
- Neuroleptic malignant syndrome
Pregnancy Lactation
- Caution during pregnancy and lactation
- Potential suppression of lactation
Precautions Warnings
- Gonioscope evaluation prior to therapy
- Monitoring of intraocular pressures
- Precipitation of angle closure
- Caution in hot weather and with other atropine-like drugs
- Anhidrosis and hyperthermia risk
- Potential Neuroleptic Malignant Syndrome
Overdose Effects
- Typical central symptoms of atropine intoxication
- Neuropsychiatric signs
- Stupor, coma, paralysis, cardiac and respiratory arrest
- Symptomatic and supportive therapy
- Gastric lavage or methods to limit absorption
- Administration of diazepam or a short-acting barbiturate
- Respiratory support, artificial respiration, vasopressor agents
- Reversal of hyperpyrexia, fluid volume replacement, acid-balance maintenance
Storage Conditions
- Store at temperature not exceeding 30°C
- Store in a dry place
- Protect from light