Tricalm 2 mg (Tablet)
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Aci limited |
| Also available as |
Indications
- Adjunct in the treatment of all forms of parkinsonism
- Useful as adjuvant therapy with levodopa
- Control of extrapyramidal disorders caused by CNS drugs
Description
- Exerts a direct inhibitory effect on the parasympathetic nervous system
- Relaxing effect on smooth musculature
- Inhibitory effect on the parasympathetic nervous system
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Binds with higher affinity to the M1 subtype
- Higher affinity for central muscarinic receptors located in the cerebral cortex
Dosage & Administration
- Individualized dosage
- Low initial dose, gradually increased
- Dosage adjustment based on patient's reaction
- Abrupt withdrawal may result in acute exacerbation of symptoms
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with alcohol or other CNS depressants
- Intensified anticholinergic effects with MAO inhibitors and tricyclic antidepressants
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Mild nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Dilatation of the colon
- Paralytic ileus
- Psychiatric manifestations like delusions, hallucinations, and paranoia
Pregnancy & Lactation
- No controlled data in animal or human pregnancy
- Caution in nursing women due to potential risk to the infant
Precautions & Warnings
- Gonioscope evaluation prior to initiation of therapy
- Monitoring of intraocular pressures
- Caution in hot weather
- Anhidrosis may occur more readily in certain conditions
- Potential for Neuroleptic Malignant Syndrome
Overdose Effects
- Typical central symptoms of atropine intoxication
- Neuropsychiatric signs such as delirium, confusion, hallucinations
- Treatment involves symptomatic and supportive therapy
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Protect from light