Tricalm 5 mg (Tablet)
Unit Price: ৳ 10.00 (5 x 10: ৳ 500.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Aci limited |
| Also available as |
Therapeutic Class
- Antiparkinson drugs
Indications
- Adjunct in the treatment of all forms of parkinsonism
- Useful as adjuvant therapy when treating parkinsonism with levodopa
- Control of extrapyramidal disorders caused by central nervous system drugs
Description
- Exerts a direct inhibitory effect upon the parasympathetic nervous system
- Has a relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Binds with higher affinity to the M1 subtype
- Higher affinity for central muscarinic receptors located in the cerebral cortex
- Lower affinity for muscarinic receptors located peripherally
- May modify nicotinic acetylcholine receptor neurotransmission
- May lead indirectly to enhanced dopamine release in the striatum
Dosage & Administration
- Initial dose should be low and then increased gradually
- Dosage should be individualized
- Initial therapy for parkinsonism
- Size and frequency of the dose needed to control extrapyramidal reactions
- Concomitant use with levodopa
- May be divided into 3 doses and taken at mealtimes
- High doses may be divided into 4 parts
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with concurrent use of alcohol or other CNS depressants
- Intensified anticholinergic effects with monoamine oxidase inhibitors and tricyclic antidepressants
Contraindications
- Hypersensitivity to trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Mild nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Dilatation of the colon
- Paralytic ileus
- Delusions
- Hallucinations
- Paranoia
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy or retention
- Tachycardia
- Dilation of the pupil
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
- Exacerbation of parkinsonism with abrupt treatment withdrawal
- Neuroleptic malignant syndrome with abrupt treatment withdrawal
Pregnancy & Lactation
- Use during pregnancy only when need has been clearly established and benefit outweighs risk
- Caution should be exercised when administered to a nursing woman
- May cause suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to initiation of therapy
- Close monitoring of intraocular pressures
- May precipitate angle closure with an increase in intraocular pressure
- Should be administered with caution in hot weather
- Anhidrosis may occur more readily
- Hyperthermia should be considered if evidence of anhidrosis exists
- Severe anhidrosis and fatal hyperthermia have occurred with the use of anticholinergics
- Neuroleptic Malignant Syndrome
Overdose Effects
- Typical central symptoms of atropine intoxication
- Neuropsychiatric signs such as delirium, disorientation, anxiety, hallucinations
- Symptomatic and supportive therapy for acute overdose
- Gastric lavage or other methods to limit absorption
- Respiratory support
- Artificial respiration
- Vasopressor agents may be necessary
Storage Conditions
- Store at temperature not exceeding 30°C in a dry place
- Protect from light