Trihexy 2 mg (Tablet)
Unit Price: ৳ 5.50 (5 x 10: ৳ 275.00)
Strip Price: ৳ 55.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of all forms of parkinsonism
- Adjuvant therapy with levodopa
- Control of extrapyramidal disorders
Description
- Exerts direct inhibitory effect on the parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Higher affinity for M1 subtype
- Modification of nicotinic acetylcholine receptor neurotransmission
- Enhanced dopamine release in the striatum
Dosage & Administration
- Individualized dosage
- Low initial dose for patients over 60 years
- Gradual dose increase
- Possible administration before or after meals
- Abrupt withdrawal may result in acute exacerbation of symptoms
- Dosage for idiopathic parkinsonism
- Dosage for drug-induced parkinsonism
- Concomitant use with levodopa
- Use in children not established
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with alcohol or CNS depressants
- Intensified anticholinergic effects with monoamine oxidase inhibitors and tricyclic antidepressants
- Increased risk for tardive dyskinesia during concomitant administration of anticholinergics and neuroleptics
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Psychiatric manifestations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy or retention
- Tachycardia
- Pupil dilation
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
- Exacerbation of parkinsonism with abrupt withdrawal
- Neuroleptic malignant syndrome
Pregnancy & Lactation
- Use during pregnancy when benefit outweighs risk
- Caution during nursing
- Potential suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Monitoring of intraocular pressures
- Potential angle closure with anticholinergic drugs
- Administration caution in hot weather
- Possible anhidrosis and hyperthermia
- Neuroleptic Malignant Syndrome risk
Overdose Effects
- Reported deaths with concomitant CNS-depressant agents
- Typical central symptoms of atropine intoxication
- Neuropsychiatric signs
- Treatment involves symptomatic and supportive therapy
- Gastric lavage to limit absorption
- Respiratory support and fluid volume replacement
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Dry place
- Protect from light