Trihexy 5 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct in the treatment of parkinsonism
- Adjuvant therapy with levodopa
- Control of extrapyramidal disorders
- Treatment of postencephalitic parkinsonism
- Treatment of arteriosclerotic parkinsonism
- Treatment of idiopathic parkinsonism
Description
- Exerts direct inhibitory effect on the parasympathetic nervous system
- Relaxing effect on smooth musculature
- Inhibitory effect on parasympathetic nervous system
Pharmacology
- Non-selective muscarinic receptor antagonist
- Binds with higher affinity to M1 subtype
- Higher affinity for central muscarinic receptors in the cerebral cortex
- Lower affinity for peripheral muscarinic receptors
- May modify nicotinic acetylcholine receptor neurotransmission
- Enhanced dopamine release in the striatum
- Mechanism of action not fully elucidated
Dosage & Administration
- Individualized dosage
- Low initial dose
- Gradual dose increase, especially in patients over 60
- Timing of administration with or after meals
- Preferable administration before meals if excessive dryness of mouth occurs
- Potential need for atropine in postencephalitic patients
- Potential adverse reactions with abrupt withdrawal
- Dosage ranges for idiopathic and drug-induced parkinsonism
- Reduced dosage when used concomitantly with levodopa or other parasympathetic inhibitors
- Best tolerated when divided into doses and taken at mealtimes
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with alcohol or other CNS depressants
- Intensified anticholinergic effects with monoamine oxidase inhibitors and tricyclic antidepressants
- Risk of tardive dyskinesia with concomitant administration of anticholinergics and neuroleptics
- Potential need for reduced dose of levodopa during concomitant therapy
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Dilatation of the colon
- Paralytic ileus
- Psychiatric manifestations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy or retention
- Tachycardia
- Pupil dilation
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
- Exacerbation of parkinsonism with abrupt treatment withdrawal
- Neuroleptic malignant syndrome
- Possible occurrence of angle-closure glaucoma
Pregnancy & Lactation
- Use during pregnancy when need is clearly established
- Benefit outweighs risk
- Potential suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Monitoring of intraocular pressures
- Possibility of angle closure with an increase in intraocular pressure
- Administration with caution in hot weather
- Potential for anhidrosis and hyperthermia
- Consideration of NMS with dose reduction or discontinuation
- Clinical manifestations of NMS
Overdose Effects
- Ingested doses up to 300 mg without fatalities
- Rare cases of death associated with overdosage in conjunction with other CNS-depressant agents
- Trihexy blood concentrations associated with fatalities
- Signs and Symptoms of overdose
- Central symptoms of atropine intoxication
- Peripheral signs of parasympathetic blockade
- Neuropsychiatric signs
- Treatment of acute overdose
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Temperature not exceeding 30°C
- Dry place
- Protection from light