Exelon Patch 10 9.5 mg/24 hr (Transdermal Patch)
Unit Price: ৳ 224.00 (1 x 30: ৳ 6,720.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Rivastigmine tartrate |
| Company | Novartis bangladesh ltd |
| Also available as |
Indications
- Symptomatic treatment of mild to moderately severe Alzheimer's dementia
- Symptomatic treatment of mild to moderately severe dementia in patients with Idiopathic Parkinson's disease
Pharmacology
- Carbamate derivative related to physostigmine
- Binds reversibly with and inactivates cholinesterase
- Increases concentration of acetylcholine at cholinergic synapses
- Relatively specific for brain acetylcholinesterase and butyrylcholinesterase
Dosage
- Rivastigmine capsule initial dose: 1.5 mg twice a day
- Dose titration based on tolerability
- Effective dose: 3 mg to 6 mg twice a day
- Recommended maximum daily dose: 6 mg twice a day
- Rivastigmine transdermal patch initial dose: 4.6 mg/24 hours
- Dose titration to maximum dosage of 13.3 mg/24 hours
- Administration: Twice a day, with morning and evening meals
Interaction
- Exaggerates effects of succinylcholine-type muscle relaxants during anaesthesia
- Caution with anaesthetic agents
- Should not be given concomitantly with other cholinomimetic substances
- No pharmacokinetic interaction with certain medications observed
Contraindications
- Contraindicated in patients with hypersensitivity to the active substance or other carbamate derivatives
Side Effects
- Most commonly reported adverse reactions: gastrointestinal including nausea and vomiting
- Female patients more susceptible to gastrointestinal adverse reactions and weight loss
Pregnancy & Lactation
- No clinical data available for pregnancy
- Excreted into milk in animals
- Not known if excreted into human milk
- Should not be used during pregnancy unless clearly necessary
- Women on rivastigmine should not breast-feed
Precautions & Warnings
- Patients with sick sinus syndrome or conduction defects, respiratory diseases
- Cholinergic stimulation may increase gastric acid secretion
- May exacerbate urinary obstruction and seizures
- Monitor body weight
- Astham or obstructive pulmonary disease
- May worsen extrapyramidal symptoms
- Lactation
Use in Special Populations
- Increased exposure in moderate renal and mild to moderate hepatic impairment
- Not recommended for use in children
Overdose Effects
- Most cases of accidental overdose have not been associated with any clinical signs or symptoms
- Symptoms may include nausea, vomiting, diarrhoea, hypertension, hallucinations, bradycardia, or syncope
- Asymptomatic overdose: no further dose for 24 hours
- Use of antiemetics and symptomatic treatment in severe cases
- In massive overdose, atropine can be used
- Scopolamine as an antidote not recommended
Therapeutic Class
- Drugs for Dementia
Storage Conditions
- Store in a cool and dry place, protected from light