Exelon Patch 10 9.5 mg/24 hr (Transdermal Patch)

Unit Price: ৳ 224.00 (1 x 30: ৳ 6,720.00)

Medicine Details

Category Details
Generic Rivastigmine tartrate
Company Novartis bangladesh ltd
Also available as
Exelon 15 mg capsule Exelon 3 mg capsule Exelon 45 mg capsule Exelon patch 5 46 mg patch Exelon patch 15 133 mg patch Exelon 6 mg capsule

Indications

  • Symptomatic treatment of mild to moderately severe Alzheimer's dementia
  • Symptomatic treatment of mild to moderately severe dementia in patients with Idiopathic Parkinson's disease

Pharmacology

  • Carbamate derivative related to physostigmine
  • Binds reversibly with and inactivates cholinesterase
  • Increases concentration of acetylcholine at cholinergic synapses
  • Relatively specific for brain acetylcholinesterase and butyrylcholinesterase

Dosage

  • Rivastigmine capsule initial dose: 1.5 mg twice a day
  • Dose titration based on tolerability
  • Effective dose: 3 mg to 6 mg twice a day
  • Recommended maximum daily dose: 6 mg twice a day
  • Rivastigmine transdermal patch initial dose: 4.6 mg/24 hours
  • Dose titration to maximum dosage of 13.3 mg/24 hours
  • Administration: Twice a day, with morning and evening meals

Interaction

  • Exaggerates effects of succinylcholine-type muscle relaxants during anaesthesia
  • Caution with anaesthetic agents
  • Should not be given concomitantly with other cholinomimetic substances
  • No pharmacokinetic interaction with certain medications observed

Contraindications

  • Contraindicated in patients with hypersensitivity to the active substance or other carbamate derivatives

Side Effects

  • Most commonly reported adverse reactions: gastrointestinal including nausea and vomiting
  • Female patients more susceptible to gastrointestinal adverse reactions and weight loss

Pregnancy & Lactation

  • No clinical data available for pregnancy
  • Excreted into milk in animals
  • Not known if excreted into human milk
  • Should not be used during pregnancy unless clearly necessary
  • Women on rivastigmine should not breast-feed

Precautions & Warnings

  • Patients with sick sinus syndrome or conduction defects, respiratory diseases
  • Cholinergic stimulation may increase gastric acid secretion
  • May exacerbate urinary obstruction and seizures
  • Monitor body weight
  • Astham or obstructive pulmonary disease
  • May worsen extrapyramidal symptoms
  • Lactation

Use in Special Populations

  • Increased exposure in moderate renal and mild to moderate hepatic impairment
  • Not recommended for use in children

Overdose Effects

  • Most cases of accidental overdose have not been associated with any clinical signs or symptoms
  • Symptoms may include nausea, vomiting, diarrhoea, hypertension, hallucinations, bradycardia, or syncope
  • Asymptomatic overdose: no further dose for 24 hours
  • Use of antiemetics and symptomatic treatment in severe cases
  • In massive overdose, atropine can be used
  • Scopolamine as an antidote not recommended

Therapeutic Class

  • Drugs for Dementia

Storage Conditions

  • Store in a cool and dry place, protected from light

Related Brands