Exelon Patch 5 4.6 mg/24 hr (Transdermal Patch)

Unit Price: ৳ 179.00 (1 x 30: ৳ 5,370.00)

Medicine Details

Category Details
Generic Rivastigmine tartrate
Company Novartis bangladesh ltd
Also available as
Exelon 15 mg capsule Exelon 3 mg capsule Exelon 45 mg capsule Exelon patch 10 95 mg patch Exelon patch 15 133 mg patch Exelon 6 mg capsule

Indications

  • Symptomatic treatment of mild to moderately severe Alzheimer's dementia
  • Symptomatic treatment of mild to moderately severe dementia in patients with Idiopathic Parkinson's disease

Pharmacology

  • Carbamate derivative
  • Cholinesterase inhibition
  • Structurally related to physostigmine
  • Binding with and inactivating cholinesterase
  • Preventing hydrolysis of acetylcholine
  • Increase in concentration of acetylcholine at cholinergic synapses
  • Relatively specific for brain acetylcholinesterase and butyrylcholinesterase

Dosage

  • Rivastigmine capsule initial dose: 1.5 mg twice a day
  • Dose titration: starting with 1.5 mg twice a day, increasing to 3 mg, 4.5 mg, and then 6 mg twice a day based on tolerability
  • Effective maintenance dose: 3 mg to 6 mg twice a day
  • Maximum daily dose: 6 mg twice a day
  • Rivastigmine transdermal patch initial dose: 4.6 mg/24 hours
  • Dose titration up to 13.3 mg/24 hours
  • Administration twice a day with meals

Administration

  • Twice a day with morning and evening meals

Interaction

  • Exaggeration of succinylcholine-type muscle relaxants effects during anesthesia
  • Caution with anaesthetic agents selection
  • No concomitant use with other cholinomimetic substances
  • Possible interference with anticholinergic medicinal products
  • No observed pharmacokinetic interaction with digoxin, warfarin, diazepam or fluoxetine

Contraindications

  • Hypersensitivity to the active substance or other carbamate derivatives

Side Effects

  • Most commonly reported adverse reactions: gastrointestinal including nausea and vomiting, especially during titration
  • Female patients more susceptible than male patients to gastrointestinal adverse reactions and weight loss

Pregnancy & Lactation

  • No clinical data available
  • Not recommended during pregnancy unless clearly necessary
  • Excretion into milk in animals
  • Not known if excreted into human milk
  • Should not be used during breastfeeding

Precautions & Warnings

  • Patients with sick sinus syndrome or conduction defects, respiratory diseases
  • May increase gastric acid secretion
  • May exacerbate urinary obstruction and seizures
  • Monitoring of body weight required
  • Caution in asthma or obstructive pulmonary disease
  • May worsen extrapyramidal symptoms

Use in Special Populations

  • Dosing recommendations for renal and hepatic impairment
  • Not recommended for use in children

Overdose Effects

  • Accidental overdose cases mostly not associated with clinical signs or symptoms
  • Possible symptoms: nausea, vomiting, diarrhea, hypertension, hallucinations, bradycardia, syncope
  • Recommendations for management and use of antiemetics
  • Use of atropine in massive overdose
  • Scopolamine not recommended as an antidote

Therapeutic Class

  • Drugs for Dementia

Storage Conditions

  • Store in a cool and dry place, protected from light

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