Rivamer 4.5 mg (Capsule)
Unit Price: ৳ 40.13 (3 x 10: ৳ 1,203.90)
Strip Price: ৳ 401.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Rivastigmine tartrate |
| Company | Sun pharmaceutical bangladesh ltd |
| Also available as |
Indications
- Symptomatic treatment of mild to moderately severe Alzheimer's dementia
- Symptomatic treatment of mild to moderately severe dementia in patients with Idiopathic Parkinson's disease
Pharmacology
- Carbamate derivative
- Structurally related to physostigmine
- Binds reversibly with and inactivates cholinesterase
- Specific for brain acetylcholinesterase and butyrylcholinesterase
Dosage
- Rivastigmine capsule
- Initial dose: 1.5 mg twice a day
- Maintenance dose: 3 mg to 6 mg twice a day
- Rivastigmine transdermal patch
- Initial Dose: 4.6 mg/24 hours
- Mild to Moderate Alzheimer's Disease and Parkinson's Disease Dementia: 9.5 mg/24 hours or 13.3 mg/24 hours once daily
Administration
- Twice a day with morning and evening meals
Interaction
- Exaggerates effects of succinylcholine-type muscle relaxants during anesthesia
- Caution in selecting anesthetic agents
- No pharmacokinetic interaction observed with digoxin, warfarin, diazepam, or fluoxetine
Contraindications
- Hypersensitivity to the active substance or other carbamate derivatives
Side Effects
- Most commonly reported adverse reactions are gastrointestinal, including nausea and vomiting
- Female patients more susceptible than male patients to gastrointestinal adverse reactions and weight loss
Pregnancy & Lactation
- Not recommended during pregnancy
- Excreted into milk in animals
- Not known if excreted into human milk
Precautions & Warnings
- Patients with sick sinus syndrome or conduction defects
- Cholinergic stimulation may increase gastric acid secretion
- May exacerbate urinary obstruction and seizures
- Monitor body weight
- May worsen extrapyramidal symptoms
Use in Special Populations
- Renal and hepatic impairment: Dosing recommendations for individual tolerability
- Not recommended for use in children
Overdose Effects
- Most cases of accidental overdose have not been associated with clinical signs or symptoms
- Symptoms may include nausea, vomiting, diarrhea, hypertension, hallucinations
- Vagotonic effect on heart rate may cause bradycardia and/or syncope
- Recommended management in cases of asymptomatic overdose
- Use of atropine in massive overdose
Therapeutic Class
- Drugs for Dementia
Storage Conditions
- Store in a cool and dry place, protected from light