Amaryl 1 mg (Tablet)
Unit Price: ৳ 6.92 (4 x 15: ৳ 415.20)
Strip Price: ৳ 103.80
Medicine Details
| Category | Details |
|---|---|
| Generic | Glimepiride |
| Company | Synovia pharma plc |
| Also available as |
Indications
- Adjunct to diet and exercise for noninsulin dependent diabetes mellitus
- Adjunct to diet, exercise, and metformin for glycaemic control
- Use in combination with insulin for blood glucose control
Pharmacology
- Decreases blood glucose concentration
- Stimulates insulin release from pancreatic beta cells
- Improves sensitivity of beta cells to glucose stimulus
- Reduces basal hepatic glucose production
- Increases peripheral tissue sensitivity to insulin
- Enhances glucose uptake
Dosage
- Initial dose based on regular blood sugar monitoring
- Gradual dose titration
- Usual dose range for well-controlled diabetes
- Timing and distribution of doses decided by physician
Administration
- Tablet must be swallowed with sufficient liquid
Interaction
- Potentiating drugs: ACE inhibitors, aminosalicylic acid, cyclophosphamide, fluoxetine
- Attenuating drugs: Barbiturates, corticosteroids, diuretics, phenytoin
- Potential for masking hypoglycaemic attack symptoms
Contraindications
- Not for insulin-dependent diabetes mellitus
- Not for diabetic ketoacidosis or coma
- Hypersensitivity to Glimepiride or sulfonylureas
- Severe hepatic dysfunction
- Severe impairment of renal function
Side Effects
- Hypoglycaemia
- Temporary visual impairment
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Urticaria
- Fall in blood pressure
Pregnancy & Lactation
- Not to be taken during pregnancy
- Necessitates changeover to insulin
- Harmful during breastfeeding
Precautions & Warnings
- Increased risk of hypoglycaemia in initial weeks of treatment
- Necessitates careful monitoring
- Prompt control with immediate carbohydrate intake
Overdose Effects
- Hypoglycaemia
- Mild symptoms require oral glucose and dosage adjustments
- Severe symptoms require hospitalization and intravenous glucose
Therapeutic Class
- Sulfonylureas
Storage Conditions
- Do not store above 30°C
- Keep away from light and out of the reach of children