Dactus 1 mg (Tablet)
Unit Price: ৳ 5.00 (6 x 10: ৳ 300.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Glimepiride |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for noninsulin dependent diabetes mellitus
- Combination use with metformin and insulin for glycaemic control
- Potential increase in hypoglycaemia risk with combined use of Dactus and insulin
Pharmacology
- Decreases blood glucose concentration
- Stimulates insulin release from pancreatic beta cells
- Improves beta cell sensitivity to glucose stimulus
- Reduces basal hepatic glucose production
- Increases peripheral tissue sensitivity to insulin
- Improves glucose uptake
Dosage
- Initial dose based on regular blood sugar monitoring
- Gradual dose titration based on glucose levels
- Usual dose range for well-controlled diabetes
- Timing and distribution of doses decided by physician
- Secondary dosage adjustment with improving diabetes control
- Dosage adjustment for changes in weight or lifestyle
- Changeover guidance from other oral antidiabetics to Glimepiride
Administration
- Must be swallowed with sufficient liquid
Interaction
- Potentiating drug interactions include ACE inhibitors, corticosteroids, MAO-inhibitors, fluconazole
- Attenuating drug interactions include barbiturates, calcium channel blockers, corticosteroids, diuretics
- Special consideration for concomitant treatment with beta-receptor blockers, alcohol intake
Contraindications
- Not suitable for insulin dependent diabetes mellitus
- Not for diabetic ketoacidosis or coma
- Hypersensitivity to Glimepiride, sulfonylureas, sulfonamides
- Severe hepatic dysfunction, impaired renal function, dialysis patients
Side Effects
- Hypoglycaemia
- Temporary visual impairment
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Urticaria
- Fall in blood pressure
Pregnancy & Lactation
- Avoid during pregnancy, changeover to insulin necessary
- Harmful during breastfeeding, changeover or discontinuation necessary
Precautions & Warnings
- Increased risk of hypoglycaemia in initial weeks of treatment
- Necessity for careful monitoring and dosage adjustment in such cases
- Prompt control of hypoglycaemia with immediate carbohydrate intake
Overdose Effects
- Potential for hypoglycaemia production
- Mild symptoms treated with oral glucose and dosage adjustments
- Severe reactions constitute medical emergencies, require hospitalization and intravenous glucose
Therapeutic Class
- Sulfonylureas
Storage Conditions
- Do not store above 30°C
- Keep away from light
- Keep out of reach of children