Dactus 3 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Glimepiride |
| Company | Acme laboratories ltd |
| Also available as |
Title
- Dactus
Categories
- Medicine
- Diabetes Management
Description
- Dactus is a sulfonylurea antidiabetic agent used to lower blood glucose levels in patients with noninsulin dependent (Type II) diabetes mellitus (NIDDM) whose hyperglycaemia cannot be controlled by diet and exercise alone. It is also indicated for use in combination with metformin or insulin when other measures are not sufficient in achieving adequate glycaemic control.
Color Options
- White
Dimensions
- Tablet form
Functions
- Lowers blood glucose levels
- Stimulates the release of insulin from pancreatic beta cells
- Improves sensitivity of beta cells to glucose stimulus
- Reduces basal hepatic glucose production
- Increases peripheral tissue sensitivity to insulin
- Enhances glucose uptake
Materials
- Glimepiride
Technical Specifications
- Hypoglycaemic action of a single dose persists for 24 hours
- Initial recommended daily dose of 1 mg
- Usual dose range in patients with well-controlled diabetes is 1 to 4 mg daily
- Should be taken immediately before a substantial breakfast or the first main meal
- Storage temperature should not exceed 30°C
Design Elements
- Tablet form
- Swallow with sufficient amount of liquid
Usability Features
- Not suitable for insulin dependent (Type I) diabetes mellitus
- Must not be used in diabetic ketoacidosis or diabetic coma
- Requires careful monitoring for risk of hypoglycaemia in the initial weeks of treatment
Interactions
- Potentiates hypoglycaemic action with ACE inhibitors, anabolic steroids, fluconazole, etc.
- Attenuates hypoglycaemic action with barbiturates, corticosteroids, diazoxide, etc.
- Concomitant treatment with certain drugs may mask the warning symptoms of hypoglycaemic attack
- Alcohol intake may unpredictably potentiate or attenuate the activity of Dactus
Dosage
- Governed by desired blood sugar level
- Lowest effective dose must be used
- Dose titration should be gradual and based on regular blood sugar monitoring
- Dose adjustment required with changes in weight, lifestyle, or other factors affecting glycaemic control
Administration
- Tablet must be swallowed with sufficient liquid
Indications
- Adjunct to diet and exercise for lowering blood glucose in NIDDM patients
- May be used in combination with metformin or insulin when other measures are inadequate
Contraindications
- Hypersensitivity to Glimepiride, other sulfonylureas, or other sulfonamides
- Severe hepatic dysfunction
- Severe impairment of renal function
- Dialysis patients
Side Effects
- Hypoglycaemia
- Temporary visual impairment
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Urticaria
- Fall in blood pressure
Pregnancy & Lactation
- Not to be taken during pregnancy; changeover to insulin necessary
- Not to be taken by breastfeeding women
Precautions & Warnings
- Initial weeks of treatment pose increased risk of hypoglycaemia
- Immediate intake of carbohydrates to control hypoglycaemia
Overdose Effects
- Can produce hypoglycaemia
- Mild hypoglycaemic symptoms should be treated aggressively with oral glucose and adjustments in drug dosage or meal patterns
- Severe hypoglycaemic reactions with coma or seizure constitute medical emergencies
Drug Classes
- Sulfonylureas
Storage Conditions
- Store below 30°C
- Keep away from light
- Keep out of the reach of children
Pharmacology
- Decreases blood glucose concentration
- Stimulates insulin release from pancreatic beta cells
- Improves beta cell sensitivity to glucose stimulus
- Reduces basal hepatic glucose production
- Increases peripheral tissue sensitivity to insulin
- Enhances glucose uptake